Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
22/12/2021 Longitudinal trajectories of work absence in patients with musculoskeletal and, or, mental health conditions
20/12/2021 Risk of major adverse cardiovascular events in patients with elevated low-density lipoprotein cholesterol, excluding atherosclerotic cardiovascular disease, atherosclerotic cardiovascular disease -risk equivalent and familial hypercholesterolemia patients
17/12/2021 Effectiveness of glucosamine on mortality and cancer incidence in patients with osteoarthritis
17/12/2021 Healthcare database study to estimate prevalence and healthcare burden of prurigo nodularis
17/12/2021 Assessing the risk of systemic diseases, such as Behcet's, systemic lupus erythematous and inflammatory bowel disease, in children that present to primary care with mouth ulcers.
14/12/2021 Time series analysis of acute kidney injury hospitalisations and gastrointestinal infections diagnosed in primary and secondary care
14/12/2021 The association between medicines and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study
13/12/2021 Covid-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from the Clinical Practice Research Datalink (CPRD)
10/12/2021 Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom
10/12/2021 The epidemiology of diseases of the circulatory system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
10/12/2021 Trends of second-line antidiabetic treatments in adults with type 2 diabetes
07/12/2021 The role of ethnicity in opioid prescribing and health service use in the last three months of life: a population-based comparative cohort study of cancer patients
07/12/2021 Association between thrombosis with thrombocytopenia syndrome (TTS) or thromboembolic events, and covid-19 vaccines
06/12/2021 Do Sodium-glucose inhibitors co-transporter-2 inhibitors (SGLT-2) decrease the risk of sudden cardiac death compared to other second or thirdline oral diabetic drugs?
06/12/2021 Drug Utilization and Safety of Glycopyrronium in children who have excess salivation
03/12/2021 An assessment of effectiveness outcomes in patients with Chronic Obstructive Pulmonary Disease switching from multiple to single inhaler triple therapy in a real-world UK population
02/12/2021 Maternal Diabetes and risk of neurodevelopmental disorders in the offspring
30/11/2021 The impact of COVID-19 on heart failure epidemiology and outcomes across primary care: a population-based cohort study
29/11/2021 Comparative Effectiveness of Umeclidinium + Vilanterol versus Inhaled corticosteroids + long- acting beta-agonists as inhaled maintenance therapy among patients with Chronic Obstructive Pulmonary Disease in a UK real-world primary care setting
29/11/2021 Optimising therapies and disease trajectories for patients living with complex multimorbidity