Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/01/2024	Epidemiology of Hypophosphatasia (HPP) in the UK: A Retrospective Cohort Study using Clinical Practice Research Data Link (CPRD)
12/01/2024	Population-level incidence, prevalence and mortality rates in diseases of regulatory interest
09/01/2024	Incidence of gastro-intestinal, lower respiratory tract, and acute otitis media infections in infants in the United Kingdom between 2012 and 2022.
09/01/2024	The epidemiology of sarcoidosis in the United Kingdon
09/01/2024	Association between leukotriene receptor antagonist use and the risk of dementia: a population based cohort study
08/01/2024	Calculating the impact of optimising preconception health among women with mental illness
08/01/2024	Developing Algorithms to Predict Individual Patient Response to Anticoagulant, Antidiabetic and Antidepressant Drug Treatment
08/01/2024	Comparing the Risk of Interstitial Lung Disease Between Oral Anticoagulants in Patients with Atrial Fibrillation: A Population-Based Cohort Study
08/01/2024	Development of prediction models for clinically relevant complications in primary care superficial venous thrombosis patients
29/12/2023	Cancer in people presenting with back pain in primary care (CanBack): a prevalence and diagnostic accuracy study
29/12/2023	Retrospective cohort analysis using Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) to investigate adherence to androgen deprivation therapy (ADT) in patients with prostate cancer
28/12/2023	Characterization of Pregnancy Outcomes in Women with Generalized Pustular Psoriasis
28/12/2023	Trends in prescription of oral anticoagulants in elderly individuals with atrial fibrillation in UK primary care
28/12/2023	Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes in patients with atrial fibrillation: effect of using a common protocol only versus a syntactically harmonized Common Data Model
28/12/2023	Comparing Direct Oral Anticoagulants to Vitamin K Antagonists on bleeding and cardiovascular outcomes: cohort study on the effect of using common data models
27/12/2023	Risks factors and causes of postnatal General Practitioner consultations and hospital admissions following perinatal mortality: a cohort study
27/12/2023	Epidemiological analysis of inflammatory eye and central nervous system conditions and their risk factors, association with infectious and immune-mediated inflammatory diseases, and health impacts. A UK population-based observational study
27/12/2023	Reinforcement Learning approach to evaluate and rank AI models that use clinical parameters to predict hospitalisation and mortality of adults with Multiple Long-Term Conditions
27/12/2023	Evaluation of foot screening in primary care in people with diabetes in England
27/12/2023	Incidence, Prevalence, and Predictors of Fibromyalgia in People with Inflammatory Arthritis: An Observational Cohort Study using the Clinical Practice Research Datalink Aurum.