Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Approved studies using CPRD Data

Date of Approval	Title
22/12/2021	Investigating the conversion rate of routine referrals for patients presenting with symptoms of possible cancer.
22/12/2021	Longitudinal trajectories of work absence in patients with musculoskeletal and, or, mental health conditions
20/12/2021	Risk of major adverse cardiovascular events in patients with elevated low-density lipoprotein cholesterol, excluding atherosclerotic cardiovascular disease, atherosclerotic cardiovascular disease -risk equivalent and familial hypercholesterolemia patients
17/12/2021	Assessing the risk of systemic diseases, such as Behcet's, systemic lupus erythematous and inflammatory bowel disease, in children that present to primary care with mouth ulcers.
17/12/2021	Effectiveness of glucosamine on mortality and cancer incidence in patients with osteoarthritis
17/12/2021	Healthcare database study to estimate prevalence and healthcare burden of prurigo nodularis
14/12/2021	Time series analysis of acute kidney injury hospitalisations and gastrointestinal infections diagnosed in primary and secondary care
14/12/2021	The association between medicines and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study
13/12/2021	Covid-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from the Clinical Practice Research Datalink (CPRD)
10/12/2021	The epidemiology of diseases of the circulatory system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
10/12/2021	Trends of second-line antidiabetic treatments in adults with type 2 diabetes
10/12/2021	Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom
07/12/2021	The role of ethnicity in opioid prescribing and health service use in the last three months of life: a population-based comparative cohort study of cancer patients
07/12/2021	Association between thrombosis with thrombocytopenia syndrome (TTS) or thromboembolic events, and covid-19 vaccines
06/12/2021	Do Sodium-glucose inhibitors co-transporter-2 inhibitors (SGLT-2) decrease the risk of sudden cardiac death compared to other second or thirdline oral diabetic drugs?
06/12/2021	Drug Utilization and Safety of Glycopyrronium in children who have excess salivation
03/12/2021	An assessment of effectiveness outcomes in patients with Chronic Obstructive Pulmonary Disease switching from multiple to single inhaler triple therapy in a real-world UK population
02/12/2021	Maternal Diabetes and risk of neurodevelopmental disorders in the offspring
30/11/2021	The impact of COVID-19 on heart failure epidemiology and outcomes across primary care: a population-based cohort study
29/11/2021	Real-world comparative effectiveness of Fluticasone Furoate+Umeclidium+Vilanterol versus multiple inhaler triple therapies among patients with Chronic Obstructive Pulmonary Disease in the United Kingdom