Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
29/11/2021 Optimising therapies and disease trajectories for patients living with complex multimorbidity
29/11/2021 Real-world comparative effectiveness of Fluticasone Furoate+Umeclidium+Vilanterol versus multiple inhaler triple therapies among patients with Chronic Obstructive Pulmonary Disease in the United Kingdom
29/11/2021 Rapid Safety Assessment of SARS-CoV-2 vaccines in 5 EU Member States using 10 electronic health care datasources
29/11/2021 Opioid prescriptions following discharge from hospital after abdominal and orthopaedic surgery: A cohort study from England
26/11/2021 Weight Loss and Weight Management in Adults with Type 2 Diabetes - an Electronic Health Record Study.
26/11/2021 Repurposing Drugs for Cancer Morbidity and Mortality based on Causal Evidence from Electronic Health Records
25/11/2021 A retrospective observational study on the burden of paroxysmal nocturnal haemoglobinuria in England using Hospital Episodes Statistics and the Clinical Practice Research Database
25/11/2021 Epidemiology of inflammatory bowel disease in the UK
25/11/2021 Safety and tolerability of osteoporosis treatments in women
24/11/2021 Frequency of migraine and the use of preventive medication in a UK primary care population
24/11/2021 The association between urine protein:creatinine ratio, end-stage renal disease and healthcare resource use in patients with lupus nephritis
23/11/2021 Epidemiology of shoulder pain and associated risk factors in the United Kingdom: a population-based study of UK primary care data using clinical practice research datalink (CPRD).
22/11/2021 Epidemiology of rheumatoid arthritis in the UK
19/11/2021 Incretin-based drugs and the risk of acute liver injury among patients with type 2 diabetes mellitus
19/11/2021 Comparative effectiveness of Umeclidinium + Vilanterol versus Indacaterol + Glycopyrronium bromide assessing exacerbation frequency, costs and resource-use among patients with Chronic Obstructive Pulmonary Disease in a UK real-world primary care setting
18/11/2021 Health Care Resource Utilization related to vascular ulcers in England
18/11/2021 The impact of painful musculoskeletal conditions on outcomes of community-acquired pneumonia
17/11/2021 Migraines and hypertensive disorders of pregnancy: a cohort study in in the UK Clinical Practice Research Datalink GOLD
17/11/2021 A cohort study of pre-pregnancy infections and risks of preterm birth
17/11/2021 Improving earlier diagnosis of coeliac disease of children and adults by predicting who is at higher risk of disease from their routine medical records