Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/03/2024	Novel analytical methods for predicting risk, diagnosis, and progression of heart failure (STRATIFYHF)
06/03/2024	A study of cardiovascular disease in patients with cancer- an electronic healthcare record analysis using primary care UK data.
06/03/2024	Systematic approaches to studying diseases in people: an Atlas of Diseases
06/03/2024	Characterization of the Alzheimer's disease population within England, including sub-group analysis of Alzheimer's disease patients with Down syndrome.
05/03/2024	Effectiveness and safety of rivaroxaban vs apixaban in patients with Atrial Fibrillation and Peripheral Artery Disease
04/03/2024	Infections and anxiety, depression, severe mental illness, or suicide and self-harm: population-based matched cohort study
04/03/2024	ASTRIS-UK: Antithrombotic treatment patterns and risk of STroke Recurrence or major bleeding in patients with non-cardioembolic Ischemic Stroke from the UK
04/03/2024	Predicting individual-level stroke risk associated with risperidone use in dementia using cardiovascular disease history
01/03/2024	COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
01/03/2024	Frailty and polypharmacy among adults aged 18 and above with cancer at the time of diagnosis
01/03/2024	Investigating adverse mental health outcomes related to glucagon-like peptide-1 receptor agonists: target trial emulation using interlinked primary and secondary healthcare records
27/02/2024	Predicting remission of type 2 diabetes following bariatric surgery: external validation of existing models and model update within England primary care electronic health records
26/02/2024	Comparing direct and indirect methods to estimate prevalence of chronic diseases using real-world data
21/02/2024	A cohort study to assess drug utilisation and long-term safety of galcanezumab in UK patients in the course of routine clinical care
21/02/2024	The epidemiological risks of non-fatal self-harm, suicide or emergency services readmission of youth following discharge from inpatient psychiatric care
21/02/2024	Assessing the utility of clinical criteria and prediction models for classification of diabetes subtypes in primary care
20/02/2024	Comparison of cardiovascular outcomes in patients with long term exposure to Evolocumab in trial and open label extension study with an external control arm using real world data
20/02/2024	Ethnic variations in risk trajectories for type 2 diabetes: an observational cohort study
19/02/2024	Association between herpes zoster vaccination and autoimmune rheumatic diseases in UK: A regression discontinuity analysis
14/02/2024	Using machine learning to understand inequalities in early-onset Type 2 Diabetes and co-occurring long-term conditions