Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
27/04/2017	Social determinants of uptake of maternal influenza and pertussis vaccine
27/04/2017	Estimating the prevalence of hyperkalemia in the UK, in patients with chronic kidney disease and/or heart failure
27/04/2017	Exploring the effects of non-alcoholic fatty liver disease (NAFLD) on non-communicable disease and healthcare utilisation
21/04/2017	Assessing the internal and external validity of confidence interval calibration in observation studies
21/04/2017	The Burden of Skin Cancer in UK Primary Care 2004-2014: a Time-Trend Analysis from the Clinical Practice Research Datalink.
21/04/2017	Sub-optimal Asthma Control in patients treated with medium or high fixed dose combination of Inhaled Corticosteroid and Long Acting Beta-Agonists in the United Kingdom's Clinical Practice Research Datalink
12/04/2017	Comparison of real-world patients with focal epilepsy to patients included in the SP0993 clinical trial
10/04/2017	Examining congenital malformations, pervasive developmental disorders and spontaneous abortion as potential adverse outcomes of influenza vaccination in pregnancy.
10/04/2017	Unmet Need and Time Waiting for Intervention with Specialist Therapy in Asthma
10/04/2017	Topical corticosteroids and risk of type 2 diabetes: a nested case-control study
10/04/2017	The Prevalence and Clinical Burden of Primary Chylomicronaemia in the UK
10/04/2017	Risk of stroke associated with acute exacerbations of chronic obstructive pulmonary disease (COPD): a self-controlled case series
10/04/2017	Autoimmune diseases and risk of glioma
06/04/2017	Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings
03/04/2017	Rotavirus vaccine effectiveness against all cause medically attended acute gastroenteritis and hospitalizations in children in England
03/04/2017	Prophylactic (Risk-reducing) Mastectomy Rates in the UK: Analysis of the Clinical Practice Research Datalink
03/04/2017	An observational retrospective cohort study to evaluate chronic disease onset associated with long-term oral corticosteroid use and the related cost impact on patients in the OPCRD / CPRD databases
03/04/2017	Prescribing Pathways to Triple Therapy in Chronic Obstructive Pulmonary Disease
31/03/2017	Drug utilization study of mirabegron (Betmiga) using real-world healthcare databases from the Netherlands, Spain, United Kingdom and Finland
30/03/2017	Short term High Density Lipoprotein cholesterol decrease and cardiovascular risk