Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
07/06/2017	Using electronic health records to facilitate earlier diagnosis of dementia
07/06/2017	Correlation of clinical outcomes with patient outcomes and resource use in patients with moderate and severe asthma.
07/06/2017	Risk factors for self-harm in people with epilepsy
06/06/2017	To assess whether landmarking and/or latent classes are better than traditional methods for assessing the relationship between changes in lung function (FEV1) over time and mortality in a primary care COPD cohort with multiple co-morbidities
06/06/2017	Development and validation of clinical prediction rules to help with decision making and early detection of multiple myeloma
02/06/2017	Safety and Effectiveness of Direct Oral Anticoagulants and Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation; A Multi-Database Cohort Study with Meta-Analysis
31/05/2017	Comparison of real world outcomes of HF patients in the UK and the USA
30/05/2017	Mortality and exacerbation rates in people with concurrent asthma and COPD compared to people with COPD alone
25/05/2017	Sex differences in risk factors and health service delivery for cardiometabolic diseases
25/05/2017	Zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in elderly in England
24/05/2017	Association between diabetes control and risk of fractures: a follow-up and a nested case control
24/05/2017	Post-authorisation safety study to assess the risk of urinary tract malignancies in relation to empagliflozin exposure in patients with type 2 diabetes: a multi-database European study
24/05/2017	Changes in cause of mortality over time in people with chronic respiratory disease in the UK
23/05/2017	Investigating the possible role of BLood eosinophil counts in guiding ANti-inflammatory treatment of COPD exAcerbations (BLANCA)
23/05/2017	Retrospective Comparative Effectiveness Study Assessing Treatment and Rates of Exacerbation among Chronic Obstructive Pulmonary Disease Subjects in England
23/05/2017	Pharmacological Heart Failure Treatment in a Population-Based Cohort using Linked Electronic Health Records
22/05/2017	Is morbidity in the UK expanding or contracting in later life? An exploratory study investigating temporal patterns in morbidity before death using primary care data
19/05/2017	The use and protective effect of antibiotics against complications of infection in patients in primary care: a cohort study using linked data from CPRD, HES, and ONS
18/05/2017	The role of hepatitis B in the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in type 2 diabetes melltius (T2DM) patients.
18/05/2017	Quantification of the association between chronic kidney disease status and cause-specific hospitalisation: a population-based cohort study in the UK