Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
01/03/2017	Drug utilisation study of new users of umeclidinium / vilanterol (UMEC/VI) and umeclidinium (UMEC) in the primary care setting
01/03/2017	Domestic violence and abuse and prescription of emergency contraception: a nested case-control study in CPRD
22/02/2017	Changes over time in the monitoring of cardiovascular risk in primary care, and the use of statins for the primary and secondary prevention of cardiovascular disease.
20/02/2017	A study on the epidemiology of treated glaucoma in the United Kingdom
17/02/2017	An evaluation of the prevalence, epidemiology and burden of illness of hypophosphatasia (HPP) in the United Kingdom.
17/02/2017	Use of hormone replacement therapy and risk of venous thromboembolism
14/02/2017	Non-specific effects of vaccination in England
14/02/2017	Estimating the effect of statin and metformin on cancer incidence and mortality in national linked electronic health records: a CALIBER study
14/02/2017	Exploring prescribing patterns, treatment trajectory and healthcare resources use of breast cancer patients in primary care to inform community pharmacy services for breast cancer survivors in England
14/02/2017	Extreme restriction design as a method for removing confounding by indication in pharmacoepidemiologic research
14/02/2017	The role of the microbiome in joint and bone disease
14/02/2017	Potentially inappropriate prescribing in people with dementia in England: a prospective cohort study.
14/02/2017	Evaluation of the risk of intracranial and gastrointestinal bleeding events in patients concurrently prescribed non-steroidal anti-inflammatory drugs and SSRI antidepressants.
14/02/2017	Developing a co-morbidity tool to predict mortality for linked primary and secondary care data.
14/02/2017	Comparative effectiveness and safety of novel oral anticoagulants in atrial fibrillation
14/02/2017	Association of urinary tract infections with antipsychotic drug use in older patients
14/02/2017	Sulphonylurea treatment and risk of myocardial infarction and all-cause mortality: a population-based cohort study
14/02/2017	The effect of month of birth on the risk of being diagnosed with learning disability and depression.
14/02/2017	Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
02/02/2017	A Drug Utilisation Study of domperidone in the United Kingdom using Clinical Practice Research Datalink (CPRD)