Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
13/10/2016	Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
13/10/2016	Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study
13/10/2016	Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
13/10/2016	Rates of cytomegalovirus among children with organ transplants
11/10/2016	The relationship between prior antibiotic exposure and antibiotic "response failure" in children presenting with acute respiratory tract infections (RTI) in primary care: an observational cohort study
04/10/2016	Optimal minimum length of treatment with buprenorphine: A European analysis of medically discontinued opioid dependent patients
30/09/2016	Estimating the annual incidence of paediatric burns across the United Kingdom
22/09/2016	Metformin and the incidence of viral-induced cancers in patients with Type-2 diabetes
14/09/2016	Trends in the prescription of oral anticoagulants in UK primary care (2009-2015)
12/09/2016	Hearing problems in adults; mapping the patient pathway and burden recorded within the NHS.
12/09/2016	Prescription trends among drug pairs with a known drug-drug interaction in primary care
24/08/2016	The role of social determinants in vaccine uptake and burden of vaccine preventable diseases
24/08/2016	Body mass index and cause-specific mortality - population-based cohort study using record linkage
23/08/2016	Hormone Therapy in Relation to Risks of Second Cancers and Mortality Among Women and Men
23/08/2016	Domperidone for insufficient lactation: a drug utilization study with interrupted time-series analysis
22/08/2016	Weight loss as a predictor of cancer and serious disease in primary care.
22/08/2016	A feasibility study to develop within primary care IT systems a computer program for flagging patients with risk factors for HIV who would benefit from having an HIV test
17/08/2016	Reproductive risk factors for prostate cancer incidence, mortality and survival
17/08/2016	Residual Risk and Burden of Cardiovascular Diseases in the United Kingdom
16/08/2016	Validating the CirCom Score in the English CPRD population