Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
08/12/2016	Drug utilisation study of new users of fluticasone furoate / vilanterol (FF/VI) in the primary care setting
08/12/2016	Development and validation of risk prediction equations and the burden of Hyperkalemia: a retrospective cohort study using routinely collected clinical practice data
08/12/2016	Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes
08/12/2016	Ethnicity, Cardiovascular Disease and the Risk of dementia
08/12/2016	Burden of Hyperkalemia among individuals seeking health care services in England
08/12/2016	Equitable access to smoking cessation therapies for older smokers
08/12/2016	Prolonged Effects of Assisted reproductive technologies on the health of women and their children: a Record Linkage study for England (PEARL)
08/12/2016	Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
08/12/2016	What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016	A comparison of the EMPA-REG OUTCOME clinical trial population with T2DM patients treated in the routine clinical practice: An exploratory study using the Clinical Practice Research Datalink (CPRD).
08/12/2016	Alternative methods to account for patients with a prior history of treatment in comparative effectiveness studies: an illustration with insulin glargine and breast cancer
08/12/2016	Assessment of the Risk of Hypertension and Cardiovascular Disease In Women with a History of Pregnancy Complications.
01/12/2016	Identification of patients with post-stroke focal spasticity of the upper or lower limb who were treated with botulinum toxin A, and health-economic evaluation of treatment with botulinum toxin A: a cohort study in England
30/11/2016	Measuring the potential adverse impact of the adoption of prescribing guidelines in primary care
24/11/2016	The association between patterns of glucocorticoid therapy and risk of developing cataracts and glaucoma in adults.
24/11/2016	Therapy decisions in newly diagnosed COPD patients in GOLD groups A and B- follow up of patients receiving different therapies. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
24/11/2016	A study estimating the occurrence of lower back pain annually in the UK
24/11/2016	Aromatase Inhibitors and Risk of Colorectal Cancer in Post-menopausal women with breast cancer
23/11/2016	An interrupted time series analysis investigating the impact of regulatory advice on nitrofurantoin prescribing in UK primary care.
16/11/2016	Impact of affluence, atopy and childhood infections on Hodgkin’s Lymphoma incidence in the UK