Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
18/10/2022	The epidemiology and case identification of Genetic Haemochromatosis in the UK General Population
18/10/2022	Incidence of and mortality due to myopericarditis associated with COVID-19 infection and COVID-19 vaccination
14/10/2022	Estimation of population-level incidence and prevalence of Covid-19 infections and reinfections
14/10/2022	The epidemiology of Behcets disease in the UK
13/10/2022	Longitudinal study of Chronic kidney disease (CKD): The Impact of risk factors on the Progression of CKD and CKD-related complications and HEalth care Resource utilisation in England (CIPHER)
13/10/2022	The Healthcare Resource Utilisation, Costs and Clinical Outcomes in Patients with Type 1 and Type 2 Diabetes Treated with First-Generation or Second-Generation Basal Insulins: A Secondary Database Study using the Clinical Practice Research Datalink linked
13/10/2022	Predicting the 2- and 5-year risk of kidney failure for patients with chronic kidney disease in the United Kingdom: external validation and update of the Kidney Failure Risk Equation
13/10/2022	A Retrospective Observational Study on Patients with Drug Resistant Epilepsy in the United Kingdom using the Clinical Practice Research Datalink
12/10/2022	Prevalence and geographic distribution of endometriosis and endometriosis symptoms and predicting laparoscopic diagnosis of endometriosis: a population-based cohort study
12/10/2022	Statins, Fenofibrate and sight-threatening diabetic retinopathy (STDR) in patients with type 2 diabetes: protocol for a cohort study using the CPRD primary care database
12/10/2022	Epidemiology and Outcomes in Children with Gender Dysphoria
11/10/2022	Trends in use of anticoagulants in Patients with Atrial Fibrillation and Chronic Kidney Disease, 2000-2021
11/10/2022	Ethnic differences in the comparative effectiveness of classes of second-line antidiabetic medicines among people with type 2 diabetes at preventing cardiovascular outcomes: a retrospective cohort study.
10/10/2022	A retrospective observational study to describe the uptake and outcomes associated with the use of Live Attenuated Influenza Vaccination in England using the Clinical Practice Research Database linked to Hospital Episode Statistics
10/10/2022	Validation of a standardised algorithm to estimate the prevalence and incidence of selected conditions in the Clinical Practice Research Datalink
06/10/2022	In-silico trials of targeted screening for abdominal aortic aneurysm using linked healthcare data
04/10/2022	A Real-World Database Study of Canagliflozin Utilization in Type 1 Diabetes Patients Over Time among European Countries
04/10/2022	The evaluation of anaemia in a primary care population: an under recognised health problem
04/10/2022	Comparison of information on diagnosis and treatment of common chronic diseases in the Million Women Study cohort and in primary care data held by CPRD
04/10/2022	A longitudinal study of antidepressant co-prescribing in people prescribed opioids for non-cancer pain