Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
13/09/2022	Advancing understanding of multi-morbidity in metabolic disease through innovation in statistical machine learning
13/09/2022	A retrospective observational cohort study in routine care settings to understand the clinical characteristics, treatment patterns, clinical outcomes and healthcare resource use in eosinophilic granulomatosis with polyangiitis (EGPA) in England
08/09/2022	Investigating longitudinal trajectories of Multiple Long-Term Conditions in adults with intellectual disabilities
07/09/2022	The utilization, safety, and effectiveness of periconceptional high-dose folic acid supplementation: a population-based cohort study
06/09/2022	Quantifying and exploring variation in diagnostic test use for children in primary care
06/09/2022	Characteristics and treatment pathways among patients receiving dual versus triple therapy in Chronic Obstructive Pulmonary Disease (COPD)..
05/09/2022	Utilisation of primary care records to enhance the preliminary assessment of new drug side effects in the World Health Organisation's global medicinal product safety database (VigiBase)
02/09/2022	The epidemiology of infectious and parasitic diseases in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
02/09/2022	Epidemiology of vasomotor symptoms and sleep disturbances in menopausal women: a retrospective cohort study in the Clinical Practice Research Datalink
02/09/2022	The SPOtting Cancer among Comorbidities (SPOCC) programme. Work Package 4: Quantification of cancer risk in patients with pre-existing health conditions
01/09/2022	Characterization of patients with atherosclerotic cardiovascular disease: a descriptive study in the UK CPRD Aurum
31/08/2022	The epidemiology of diseases of the musculoskeletal system and connective tissue in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
31/08/2022	A study of the prescribing trends for antiepileptic drugs
26/08/2022	A retrospective observational study on the burden and healthcare resource use of adult patients with moderate-to-severe obstructive sleep apnoea in England using the Clinical Practice Research Database linked to Hospital Episode Statistics
24/08/2022	Developing better understanding of physical and functional outcomes of mental health in people with chronic pain
23/08/2022	Optimising therapies and disease trajectories for patients living with complex multimorbidity in primary and secondary linked datasets
23/08/2022	The association between Obstructive Sleep Apnoea and Non-Alcoholic Fatty Liver Disease and Fragility Fracture in patients with Type 2 Diabetes: a retrospective cohort study
23/08/2022	Investigation of the use of inhaled corticosteroids (ICS) and antacids in patients with idiopathic pulmonary fibrosis (IPF) on mortality, respiratory infections and pneumonia using a cohort design
22/08/2022	Understanding and optimising orthopaedic patient journeys using clustering, simulation, and Artificial Intelligence (AI) driven methods
18/08/2022	The epidemiology of mental and behavioural disorders in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions