Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
21/01/2022	Severe Sickle Cell Disease and Transfusion-dependent beta-thalassaemia: Economic and Clinical Burden of Disease in England
20/01/2022	An exploration of primary and secondary care datasets for tReAtment Duration and survIval outcomes of liposarcoma patients in the UK using electronic medical recordS (RADIUS)
18/01/2022	Antidepressant treatment and outcomes in the context of polypharmacy in adults with comorbid depression and type 2 diabetes
17/01/2022	Proton pump inhibitors and the incidence of inflammatory bowel disease: a population-based cohort study
13/01/2022	Sodium-glucose co-transporter 2 inhibitors and early bladder cancer events: An international multi-site study
13/01/2022	Previous gestational diabetes mellitus and testing for type 2 diabetes mellitus and cardiovascular disease: variation by region and GP practice in the UK
13/01/2022	Risk of side-effects from long-term use of inhaled steroids in asthma
13/01/2022	A retrospective cohort study assessing biomarker measurements, cardiovascular risk scores, and cardiovascular complications in men diagnosed with prostate cancer and prescribed gonadotropin-releasing hormone agonist or antagonist treatment in England
10/01/2022	Effectiveness of allopurinol on mortality and cardiovascular events in patients with gout
06/01/2022	Presenting Complaints for Prostate Cancer in Primary Care
06/01/2022	Identifying coincident drugs that alter headache progression and remission.
06/01/2022	Health care resource utilization in pyruvate kinase deficient patients in the UK: a retrospective database study
05/01/2022	Impact of the coronavirus disease (COVID-19) pandemic on incidence of tics in children and young people: a population-based cohort study
05/01/2022	Endometrial cancers: A propensity score matched study assessing different routes of surgery, and a prospective cohort study to investigate the disease epidemiology and estimate future incidence
23/12/2021	RECORD-HF: A REtrospective COhort study of heart failure-Related outcomes in patients who are prescribed a loop Diuretic without a diagnosis of Heart Failure
23/12/2021	Patterns and clinical outcomes of cardiovascular medication use after a cancer diagnosis in patients with heart failure
23/12/2021	Do features occurring prior to MS diagnosis vary according to background: a nested case control study
23/12/2021	A post-authorisation (post-marketing) observational study using existing secondary health data sources to evaluate the association between exposure to the AstraZeneca COVID-19 vaccine (AZD1222) and safety concerns
23/12/2021	Comparative effectiveness of Umeclidinium+Vilanterol versus Tiotropium Bromide+Olodaterol among patients with Chronic Obstructive Pulmonary Disease in a real-world primary care setting in the UK
22/12/2021	Longitudinal trajectories of work absence in patients with musculoskeletal and, or, mental health conditions