Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
09/11/2021	Incretin-based drugs and the prevention of exacerbations of chronic obstructive pulmonary disease among patients with type 2 diabetes mellitus
09/11/2021	Impact of COVID-19 vaccination on preventing long COVID: a population-based cohort study using NHS data
05/11/2021	The management of gout in primary and secondary care in England and Wales: a descriptive study
02/11/2021	Determining patients at risk of first Chronic Obstructive Pulmonary Disease (COPD) exacerbation in UK Global Initiative for Chronic Obstructive Lung Disease (GOLD) A and B Chronic Obstructive Pulmonary Disease (COPD) patients
02/11/2021	Quantification of potential undiagnosed Pulmonary Arterial Hypertension (PAH) patients among patients with chronic respiratory disorders and PAH-related cardiovascular conditions through machine learning models in the UK CPRD-HES databases
01/11/2021	Intimate partner violence, parental substance misuse and the mental health of parents & children - a retrospective open birth cohort
29/10/2021	Investigating the applicability of regression discontinuity in electronic health record for assessing the effectiveness of prostate-specific antigen screening for the prevention of prostate cancer
28/10/2021	MINERVA: Metadata for data discoverability and study replicability in observational studies – quantitative metadata describing the CPRD Aurum data source
27/10/2021	Bleeding events and adverse reactions in UK patients with non-valvular atrial fibrillation (NVAF) treated with edoxaban
27/10/2021	The impact of the use of immunotherapy and risk of type I diabetes mellitus (TIDM) and other immune related adverse events: a population-based observational cohort study
26/10/2021	What biopsychosocial factors are associated with abortions in primary care in Britain? A case control study comparing women aged 13 to 54 who had abortions compared with those who did not.
19/10/2021	Falling through the cracks: patterns of care for people with markedly elevated blood pressure seen in English primary care
15/10/2021	Examining patterns and clusters of comorbidities in people with psoriasis
15/10/2021	Estimated prevalence of multiple long term conditions
12/10/2021	Influenza and pneumococcal vaccination in adults with common inflammatory conditions treated with immune suppressing drugs: a study of vaccine uptake, clinical effectiveness and vaccine safety.
11/10/2021	Atherosclerosis following Deep Vein Thrombosis (ADVenT) study
08/10/2021	The safety of antipsychotic drugs in children and youth with attention deficit and hyperactivity disorder
08/10/2021	The effectiveness of faster aspart insulin versus other bolus insulins on glycaemic control in a real-world setting
08/10/2021	Aclidinium Bromide Post-Authorization Safety Study (PASS) to Evaluate the Risk of Cardiovascular Endpoints: Arrhythmias
08/10/2021	Comparison of effectiveness and safety of direct oral anticoagulant versus low molecular weight heparin treatment for active cancer-associated venous thromboembolism