Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
26/04/2022	Investigating apomorphine sub-cutaneous injection daily dose and duration among people with Parkinson’s disease
26/04/2022	Methodological challenges in the use of propensity scores in distributed networks
26/04/2022	The epidemiology of diseases of the digestive system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
22/04/2022	Assessing healthcare resource use of treating Type 2 Diabetes over time: A population-based case control study
22/04/2022	The epidemiology of diseases of the nervous system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
22/04/2022	Skin and Soft Tissue Infections incidence in England and related health care utilisation between 2010 and 2020
19/04/2022	Does having Covid-19 whilst pregnant increase the risk of pregnancy loss (miscarriage or stillbirth)? A matched cohort study
14/04/2022	Post-discharge care following acute kidney injury: a population-based cohort study
14/04/2022	Artificial Intelligence and Multimorbidity: Clustering in Individuals, Space and Clinical Context (AIM-CISC)
13/04/2022	Post-authorisation safety study to assess cardio- and cerebrovascular outcomes in patients with chronic obstructive pulmonary disease initiating a fixed triple therapy administered via dry powder inhaler compared to pressurized metered dose inhaler(TRIBE)
13/04/2022	A retrospective cohort study examining the epidemiology and healthcare resource use of Leber hereditary optic neuropathy in England
13/04/2022	Epidemiology, healthcare utilisation and related costs of opioid induced constipation associated with methadone maintenance therapy
13/04/2022	The role of maternal mental health on vaccine timeliness in early childhood.
08/04/2022	Predicting risk of major gastro-intestinal bleed associated with use of non-steroidal anti-inflammatory drugs. Development and validation of a risk model in primary care patients.
07/04/2022	Dihydropyridine calcium channel blockers and the risk of pancreatic cancer: a population-based cohort study
07/04/2022	Development of a system agnostic algorithm for a Mother Baby Link in the CPRD primary care data.
05/04/2022	The frequency of stroke in patients with sickle cell disease in the UK - a descriptive study.
05/04/2022	Pathways to the diagnosis of Interstitial Lung disease in patients with Rheumatoid Arthritis
05/04/2022	Association between sodium-glucose cotransporter-2 inhibitors and multi-organ benefit in patients with type 2 diabetes
05/04/2022	Assessing influenza vaccine uptake and associated health outcomes in pregnant women and their infants in the UK: a cohort study