Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
14/02/2022 Temperature extremes and clinical vulnerability in England; development of a risk stratification tool for primary care use
14/02/2022 PrevaLence And intercoNnEcTivity of Cardiovascular, Renal, and Metabolic (CRM) diseases in UK adults, 2005-2020 (PLANET - CRM)
10/02/2022 Sodium-glucose cotransporter-2 inhibitors and the risk of lung cancer among patients with type 2 diabetes
09/02/2022 Efficacy and safety of anticoagulants in atrial fibrillation patients with history or risk of falls in England using the Clinical Practice Research Datalink and Hospital Episode Statistics datasets, the Liverpool Atrial Fibrillation-Falls project.
09/02/2022 An observational database study to estimate the burden of respiratory syncytial virus (RSV) infections using multiple databases in the United Kingdom, 2004 to 2019, by age and risk group
08/02/2022 Delays in Diagnosis of Degenerative Cervical Myelopathy: A Population-Based Study using the Clinical Practice Research Datalink
07/02/2022 Comparing diagnosis of giant cell arteritis in primary care and secondary care and describing the patterns of blood pressure and haemoglobin measurements: an observational feasibility study using CPRD Aurum and Hospital Episode Statistics
01/02/2022 Primary care recording of burden of illness and outcomes amongst patients with achondroplasia: A feasibility study
01/02/2022 Utilising Electronic Health Records to explore associations between anticholinergic medication use, delirium and subsequent dementia.
01/02/2022 Validation of an algorithm to link electronic medical records of mothers to their children's medical records, in CPRD Aurum
01/02/2022 Primary care models for the detection of clinically significant prostate cancer: the ProsDetect study
01/02/2022 How the predictions of algorithms used in healthcare provision change: an investigation using COVID-19 and Cardiovascular disease risk prediction case studies.
01/02/2022 Quality and completeness of primary care recording of hypertension treatment with amlodipine, outcomes, and comorbidities: A feasibility study
31/01/2022 Predicting healthcare utilisation using diagnoses in primary and secondary care: a study using linked UK primary and secondary care data
27/01/2022 An observational retrospective cohort study describing clinical outcomes and utilisation of healthcare resources among persons with COVID-19 in England, stratified by infection severity and selected comorbidities
27/01/2022 Patient characteristics, treatment patterns, adverse outcomes, health care resource utilisation and costs in paediatric and adult patients with a diagnosis of eosinophilic esophagitis in England: A real-world observational retrospective cohort analysis
25/01/2022 A retrospective cohort study assessing clinical outcomes in patients with cardiac resynchronisation therapy or implantable cardioverter defibrillators in England
25/01/2022 Exploring the use of different definitions of acute exacerbation of chronic obstructive pulmonary disease in routinely collected electronic healthcare records and investigating how varying definitions may affect study results
24/01/2022 Impact of postpartum management of hypertensive disorders of pregnancy on long-term Cardio-vascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records
24/01/2022 Evaluation of the all-cause mortality and healthcare resource use associated with early versus late treatment initiation of rifaximin-alpha 550mg in hepatic encephalopathy patients.