Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
29/11/2021	Real-world comparative effectiveness of Fluticasone Furoate+Umeclidium+Vilanterol versus multiple inhaler triple therapies among patients with Chronic Obstructive Pulmonary Disease in the United Kingdom
29/11/2021	Rapid Safety Assessment of SARS-CoV-2 vaccines in 5 EU Member States using 10 electronic health care datasources
26/11/2021	Weight Loss and Weight Management in Adults with Type 2 Diabetes - an Electronic Health Record Study.
25/11/2021	Safety and tolerability of osteoporosis treatments in women
25/11/2021	Epidemiology of inflammatory bowel disease in the UK
25/11/2021	A retrospective observational study on the burden of paroxysmal nocturnal haemoglobinuria in England using Hospital Episodes Statistics and the Clinical Practice Research Database
24/11/2021	Frequency of migraine and the use of preventive medication in a UK primary care population
24/11/2021	The association between urine protein:creatinine ratio, end-stage renal disease and healthcare resource use in patients with lupus nephritis
23/11/2021	Epidemiology of shoulder pain and associated risk factors in the United Kingdom: a population-based study of UK primary care data using clinical practice research datalink (CPRD).
22/11/2021	Feasibility assessment of women of childbearing potential (WOCBP) and pregnant women with influenza and prescribed medication exposures for influenza in CPRD
22/11/2021	Epidemiology of rheumatoid arthritis in the UK
19/11/2021	Comparative effectiveness of Umeclidinium + Vilanterol versus Indacaterol + Glycopyrronium bromide assessing exacerbation frequency, costs and resource-use among patients with Chronic Obstructive Pulmonary Disease in a UK real-world primary care setting
19/11/2021	Incretin-based drugs and the risk of acute liver injury among patients with type 2 diabetes mellitus
18/11/2021	Health Care Resource Utilization related to vascular ulcers in England
18/11/2021	The impact of painful musculoskeletal conditions on outcomes of community-acquired pneumonia
17/11/2021	The prevalence of Alzheimer's disease in England across deprivation groups: A Clinical Practice Research Datalink study
17/11/2021	Migraines and hypertensive disorders of pregnancy: a cohort study in in the UK Clinical Practice Research Datalink GOLD
17/11/2021	Severe mental illness (SMI) and cancer screening inequalities: a cross section study
17/11/2021	A cohort study of pre-pregnancy infections and risks of preterm birth
17/11/2021	Improving earlier diagnosis of coeliac disease of children and adults by predicting who is at higher risk of disease from their routine medical records