Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
09/03/2022	Anticholinergic bladder drugs and associations with dementia risk
09/03/2022	Has the incidence of giant cell arteritis in England and Northern Ireland been influenced by the covid-19 pandemic? A case cohort study using CPRD Aurum data
09/03/2022	Utilization of Low-Dose Aspirin during Pregnancy and Impact of National Institute for Health and Care Excellence Guidelines on Prescription Trends
09/03/2022	Cohort study investigating the natural history of gout in UK general practice
08/03/2022	The risk of pneumonia in COPD patients and COPD patients with concomitant bronchiectasis, using inhaled steroids: a UK case-control study
08/03/2022	Variations in the management of Inflammatory Bowel Disease over time: How has Covid-19 effected inflammatory bowel disease patients?
03/03/2022	Safety of the Novavax COVID-19 vaccine in England: a post-authorisation safety study using data from the Clinical Practice Research Datalink (CPRD)
02/03/2022	Systemic lupus erythematosus related organ damage and mortality
02/03/2022	Developing evidence based optimal testing strategies to monitor long term conditions in primary care
02/03/2022	Development of a personalised exacerbation prediction risk model for adults with asthma in England
01/03/2022	Clinical and economic burden of uncontrolled severe asthma patients with low blood eosinophil levels in the UK: A retrospective observational study
25/02/2022	Healthcare resource utilisation and clinical burden in obstructive hypertrophic cardiomyopathy (oHCM) patients pre-diagnosis; assessment of predictive factors for diagnosis of oHCM
24/02/2022	Incretin-based drugs and the risk of melanoma and keratinocyte carcinoma among patients with type 2 diabetes mellitus
24/02/2022	The Incidence of Common Autoimmune Diseases in People with COVID-19: a Retrospective Cohort Study using the Clinical Practice Research Datalink.
23/02/2022	Frailty in relation to Diabetic Foot Ulcer risk and the risk factors associated with adverse outcomes in patients with Diabetic Foot Ulcer: An observational study
22/02/2022	Diagnostic prediction models for ovarian and non-ovarian cancer in primary care (Ovatools): an external validation and health economic study
21/02/2022	Post-Authorization Active Surveillance Safety Study Using Secondary Data to Monitor Real-World Safety of Spikevax in Europe
16/02/2022	Using Real-World Data to Compare Mometasone Furoate-Formoterol Combination Versus Mometasone Furoate in Reducing Asthma Exacerbations in Persistent Asthmatics
14/02/2022	PrevaLence And intercoNnEcTivity of Cardiovascular, Renal, and Metabolic (CRM) diseases in UK adults, 2005-2020 (PLANET - CRM)
14/02/2022	Ethnic inequities in preventive and avoidable healthcare during infancy and early childhood: A population-based cohort study using linked electronic health records in England