Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
30/07/2020	Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
30/07/2020	The economic burden of dementia and associated research funding in the United Kingdom in 2018: a comparative study of four chronic conditions
30/07/2020	An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data
29/07/2020	Re-evaluating the cost effectiveness of implantable cardioverter defibrillator (ICD) or cardiac resynchronisation therapy with defibrillation (CRT-D) for heart failure using real world data from the Clinical Practice Research Datalink
29/07/2020	Real-world utilization of and comparative outcomes arising from novel oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
29/07/2020	Adverse pregnancy outcomes and maternal cardiometabolic health: an observational cohort study using electronic medical records
23/07/2020	Exploring patterns of healthcare resource utilisation and COPD exacerbations in patients with chronic obstructive pulmonary disease for health technology assessment
22/07/2020	Which patients with visual impairment need to access Falls Services? – Using big data to bridge the intervention gap
20/07/2020	Determining the applicability and feasibility of using regression discontinuity in electronic health record data
20/07/2020	Prevalence of haematuria and its association with risk of urinary tract cancer: a case-control study using real-world data from UK primary care
16/07/2020	Strengthening the Evidence-Base for Drug-Disease Interactions in Older Adults
16/07/2020	Bleeding events and adverse reactions in UK patients with venous thromboembolism (VTE) treated with edoxaban
16/07/2020	The SPOtting Cancer among Comorbidities (SPOCC) programme. Work Package 1: Investigating comorbidities’ impact on intermediate cancer outcomes associated with the diagnostic process; a retrospective cohort study
16/07/2020	The effectiveness of aspirin in preventing COPD exacerbations: A prevalent new-user cohort study
14/07/2020	A descriptive analysis of Pompe disease and Fabry disease based on UK electronic primary healthcare records and linked secondary care data
13/07/2020	Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch
13/07/2020	Antibiotic prescribing and risk of herpes zoster: a case-control study
10/07/2020	Glycaemic control and diabetes-related health outcomes: longitudinal HbA1c trajectories, cumulative morbidity, and disease transitions in people with type 2 diabetes
09/07/2020	Asthma epidemiology, prevalence of asthma modifiable factors and healthcare utilisation due to asthma in England, Scotland, Wales, Northern Ireland and the UK
08/07/2020	Retrospective cohort study on first-time use of insulin detemir for diabetes type 2 glycaemic control in elderly and multimorbidity patients living in the United Kingdom