Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
29/10/2019	Temporal and regional trends in neuromuscular disease prevalence and incidence, and the health and healthcare of people with neuromuscular conditions in the UK between 2000-2018
29/10/2019	Trends in gabapentinoid prescribing and risk of adverse events: an observational study in UK primary care using the Clinical Practice Research Datalink
25/10/2019	Health care demand modelling – Time series analysis of the incidence and prevalence of multiple chronic conditions and comorbidities in England from primary care data
24/10/2019	Burden of hip dislocation following total hip arthroplasty in England.
22/10/2019	The IMPORTANT Study: Investigating myeloproliferative neoplasms, patient outcomes and treatment of thromboembolic events in the UK
21/10/2019	Trends in prescription of antidepressants and coprescription with other psychotropic medications in children and adolescents in UK primary care
16/10/2019	Demographics, Treatment Pathways and Healthcare Resource Use among Patients with Secondary Progressive Multiple Sclerosis in England: The DEPTH Study
16/10/2019	Use of sodium-glucose co-transporter-2 inhibitors (SGLT-2-Is) and risk of lower limb amputation.
16/10/2019	Epidemiology of Paget’s disease in the UK: Is it still changing?
11/10/2019	Effect of raised cardiovascular risk on the rates of acute respiratory infections and subsequent cardiovascular complications: a cohort study using electronic health records
11/10/2019	Low-dose oral glucocorticoid therapy and risk of osteoporotic fractures in patients with rheumatoid arthritis: a cohort study using CPRD
09/10/2019	Cardiovascular prognosis in patients with undiagnosed chest pain: an electronic health record cohort study
09/10/2019	Cohort study examining mortality and physical morbidity outcomes among patients diagnosed with an eating disorder
09/10/2019	Characterization of the deterioration of type 2 diabetes in patients with a subsequent diagnosis of pancreatic cancer – A descriptive study
09/10/2019	Cardiovascular risk and outcomes in the UK population before and after cancer treatment: a cohort study
08/10/2019	Post Authorisation Safety Study (PASS) to Evaluate the Risks of Hepatotoxicity and Nephrotoxicity from Administration of Methoxyflurane (Penthrox) for Pain Relief in Hospital Accident & Emergency Departments in the United Kingdom
08/10/2019	The Plan-it study: The acceptability and feasibility of a planned pre-pregnancy weight loss intervention
07/10/2019	Global prescribing trends in antidepressants, opioids and lithium
07/10/2019	Impact of variability in patient characteristics on effect estimates in observational studies: a retrospective multi-cohort study of rivaroxaban versus warfarin
03/10/2019	Polypharmacy and the impact of drug interactions with direct oral anticoagulants (DOACs)