Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
26/11/2019	A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression
21/11/2019	Safety of colchicine prophylaxis when initiating urate-lowering therapy for gout and prognostic factors for adverse events: an observational study in UK primary care using the Clinical Practice Research Datalink
20/11/2019	Examining variations in prescribing safety for patients with mental illness in UK primary care
20/11/2019	Diabetes Mellitus and frozen shoulder: risk, diagnosis and prognosis
20/11/2019	Comparative effectiveness of the cardiorenal disease outcomes between SGLT-2i and DPP-4i medication in population with type 2 diabetes – an observational study across England
20/11/2019	Co-prescribing of aldosterone antagonist and renin-angiotensin system drugs for heart failure in the UK primary care: assessing the impact of regulatory action
20/11/2019	Dementia in South Asians: tailoring risk prediction by ethnicity
15/11/2019	Characteristics, treatment patterns and burden of illness in UK asthma patients prescribed ICS/LABA and LAMA
15/11/2019	Utilization and comparative effectiveness and safety of long-acting insulins and Neutral Protamine Hagedorn (NPH) in patients with type 2 diabetes
13/11/2019	Epilepsy prevalence and incidence in the UK
13/11/2019	The Incidence and Associated Healthcare Resource Burden of Thrombotic Thrombocytopenic Purpura (TTP) in England based on Healthcare Datasets
11/11/2019	Incidence of adverse events among adult users of insulin and apomorphine pumps in the United Kingdom Clinical Practice Research Datalink GOLD: a descriptive study
08/11/2019	Eosinophilic asthma phenotypes and associated clinical outcomes
08/11/2019	The association between anticoagulants and cancer incidence among individuals with atrial fibrillation.
06/11/2019	DISCOVER CKD: An observational study incorporating UK CPRD data to evaluate and describe the journey and management of patients with chronic kidney disease (CKD).
04/11/2019	Retrospective Cohort Study of Medium-dose ICS/LABA patients who received add-on in comparison to patients who titrated to high-dose ICS/LABA in the United Kingdom
01/11/2019	Patient and clinical characteristics of new users to single or multiple inhaled triple therapy in patients with COPD in the UK
01/11/2019	Which histological subtypes of lung cancer exhibit underlying pre-diagnostic thrombocytosis?
01/11/2019	Comparative effectiveness and safety of NOACs versus warfarin in UK patients with non-valvular atrial fibrillation and type 2 diabetes: a retrospective cohort study
30/10/2019	Association of chronic kidney disease with frailty and mortality in the multi-ethnic UK population: a CPRD study