Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
30/08/2019	GLP-1 receptor agonists and the risk of anaphylactic reactions among patients with type 2 diabetes
28/08/2019	Adverse childhood experiences: incidence, prevalence, determinants and outcomes across primary and secondary care
28/08/2019	Real-world observational study to evaluate probability of achieving glycemic control after initiation of glucagon-like peptide-1 receptor agonists or basal insulin in T2DM patients (UK CPRD database)
28/08/2019	Childhood poisoning substance trends in England, 1998-2018
28/08/2019	A real-world study comparing the effectiveness and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in patients with type 2 diabetes
28/08/2019	Eating Disorders in Mothers and subsequent long term health effects in their children
22/08/2019	Equity dynamics of multimorbidity in England over time: a descriptive study on trends of incident and prevalent multimorbidity by age, sex, and socioeconomic status
22/08/2019	Comparative Long-Term Effectiveness of Treatments for Patients with Drug-Resistant Epilepsy: a descriptive study
20/08/2019	A multi-database retrospective study of the comparative efficacy and safety of SGLT2 inhibitors in the management of type 2 diabetes (EMPRISE-UK)
20/08/2019	Estimating primary and secondary healthcare resource costs for people with type 1 and type 2 diabetes in the United Kingdom
15/08/2019	Eating Disorders in Mothers and subsequent pregnancy outcomes
12/08/2019	Understanding the use of long-term antibiotics for acne in the United Kingdom
12/08/2019	Statins and the risk of Venous Thromboembolism
08/08/2019	Characteristics and Treatment Patterns of Patients with Chronic Obstructive Pulmonary Disease (COPD), Initiating Tiotropium+Olodaterol or Other Maintenance Therapies in the UK: A Database Study
07/08/2019	The long-term impact of vaginal surgical mesh devices in UK primary care: a cohort study in the CPRD
07/08/2019	Immortal Time Bias in Comparative Drug Safety Studies in Pregnancy
05/08/2019	Occurrence and consequences of Langerhans cell histiocytosis, Malignant Histiocytosis, Erdheim-Chester Disease and Haemophagocytic Lymphohistiocytosis: a population based cohort study
05/08/2019	Association of Polycystic Ovary Syndrome with patient and offspring cardiometabolic outcomes: a retrospective, observational study
31/07/2019	A non-interventional retrospective study in England and Scotland estimating the economic burden of moderate-to-severe chronic pain due to osteoarthritis (OA) or chronic low back pain (CLBP)
31/07/2019	Use of the STarT Back Screening Tool for Low Back Pain in Primary Care