Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
03/01/2020	Evaluation of the associations between variability of cardiovascular risk factors and risk of cardiovascular and non-cardiovascular diseases
03/01/2020	CARPE-DM (CARdiometabolic multi-morbidity and CKD-related outcomes: A clinical Practice rEsearch datalink observational study in Diabetes Mellitus)
03/01/2020	Heart failure burden of illness and characterisation of patients by treatments, comorbidities and ejection fraction – an observational study
03/01/2020	Cardiomyopathy in pregnancy and future risk of cancer: a cohort study of women in the United Kingdom between 1987 and 2017
20/12/2019	Comparative effectiveness and safety of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of major cardiovascular events, cancer and renal outcomes
20/12/2019	Colorectal cancer survivorship & the development of kidney diseases
20/12/2019	Healthcare resource utilisation attributable to Distal Renal Tubular Acidosis in adult and paediatric population in the UK: A matched group retrospective study
20/12/2019	Developing risk prediction models to support individualised HbA1c target setting using routinely collected primary and secondary care data from the United Kingdom (UK)
20/12/2019	Bringing Innovative Research Methods to Clustering Analysis of Multimorbidity (BIRM-CAM)
20/12/2019	Risk of skin cancer associated with use of thiazides and thiazide-like diuretics: a cohort study
18/12/2019	A study of life years lost and care pathways in people with learning disabilities: a real-world observational study
18/12/2019	Cardiovascular Risk Profiles: Comparing the Glucagon-Like Peptide-1 Receptor Agonist Cardiovascular Outcomes Trials REWIND, LEADER and SUSTAIN-6 in a Real World Population with Type 2 Diabetes in UK Primary Care
18/12/2019	Stage at diagnosis and subsequent health care provision for patients with alcoholic liver disease and the association with their socioeconomic status
18/12/2019	Lung function decline and rate of cardiovascular disease in COPD patients in England
17/12/2019	Characterisation of asthma in young paediatric patients: a UK retrospective analysis
17/12/2019	External validation study investigating the association between hormonal contraceptives and asthma onset in females of reproductive age
17/12/2019	Improved characterization of the overlap syndrome of heart failure, diabetes mellitus and chronic kidney disease
17/12/2019	The use of real-world data to emulate a clinical trial: assessing the impact of temporality, comparator choice and methods of adjustment
13/12/2019	Assessment of production batch information of vaccines in the Clinical Practice Research Datalink
12/12/2019	The association between biochemical control and clinical outcomes in acromegaly: an observational study using routine UK health data