Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
31/01/2020	Predictors of cardiovascular event risk in a population with Atherosclerotic Cardiovascular Disease (ASCVD) or Heterozygous Familial Hypercholesterolemia (HeFH)
30/01/2020	Factors associated with progression of chronic kidney disease from stage 3 to 5 in patients with diabetes (PRIDE)
30/01/2020	Late or missed childhood vaccination: identifying the determinants and estimating the impact on subsequent child health outcomes
30/01/2020	Impact of Covid-19 on primary care contact, referrals to follow-up care and patient outcomes after emergency department and primary care presentations for self-harm: cohort study using linked hospital and primary care health records
27/01/2020	Prevalence, Treatment Pathway and Patient Outcomes of Primary Hypercholesterolaemia and Dyslipidaemia in England: The 4Ps Study
23/01/2020	Use of Hydrochlorothiazide and the Risk of Melanoma and Non-Melanoma Skin Cancer: A Population-Based Cohort Study
23/01/2020	Changes in serum creatinine values during and after pregnancy in a cohort of women with or without pre-existing chronic kidney disease
21/01/2020	Developing and Validating a Prognostic Model for All-Cause Mortality Patients with Heart Failure
17/01/2020	Mapping the risk of infections in patients with multiple sclerosis: A multi-database study in the United Kingdom Clinical Practice Research Datalink GOLD and Aurum
17/01/2020	Examining neurologic and thromboembolic risks when using skeletal muscle relaxants with warfarin
16/01/2020	Examining the prevalence and adverse effects of drug-drug interactions involving antipsychotic medication
16/01/2020	An observational study of comorbidities and clinical events among patients with Progressive Supranuclear Palsy (PSP)
16/01/2020	Investigating the risk of serious adverse events associated with the use of gabapentinoids in patients with chronic non-cancer pain in primary care
15/01/2020	Oral anticoagulants and incidence of dementia in patients with non-valvular atrial fibrillation
09/01/2020	Feasibility study to assess the viability of a future observational study of the effects of corticosteroids on the incidence and progression of type 2 diabetes
08/01/2020	GARFIELD-AF in Primary care – Optimising prediction of mortality, stroke and major bleeding for patients with atrial fibrillation using routinely collected primary care electronic health records
08/01/2020	Comparison of the prevalent new user and active comparator new user designs for assessing the real-world safety and effectiveness of medications
06/01/2020	Sodium-glucose transport protein 2 inhibitors and the risk of early breast cancer
06/01/2020	Treatment Patterns, Effectiveness and Safety for Secondary Stroke Prevention among Patients with Ischemic Stroke or Transient Ischemic Attack
06/01/2020	Use of electronic primary care records to obtain control populations for assessing excess risk of long-term morbidity and mortality in chronic diseases