Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/06/2019	An observational, retrospective, matched case-control study to assess the effectiveness of Priorix vaccine in children born after 2004 in the United Kingdom (UK)
05/06/2019	Evaluation of the ePACT2 national polypharmacy prescribing indicators
31/05/2019	Temporal trends in the incidence of autism spectrum disorder in children and variation in diagnosis rates: A retrospective study using UK electronic medical records
31/05/2019	Dynamic Transmission Model for Rotaviral Infection Before and After Introduction of the Rotarix Vaccine in the UK and Belgium: Modelling Hospital Admission Rates
31/05/2019	An observational study to establish the cardiovascular-renal-metabolism comorbidity epidemiology and healthcare utilisation in England
31/05/2019	Trends in cancer incidence and mortality in people with pre-diabetes and diabetes among different ethnicities
29/05/2019	Using routinely collected healthcare data to predict onset of AF and determine subsequent disease trajectories
29/05/2019	Anticholinergic antidepressant drugs and long-term risk of dementia
29/05/2019	An exploratory study of antibiotic prescribing in the CPRD Aurum database
29/05/2019	The Impact of Varying the Inception Cohort on the Performance of Risk Prediction Models for Time-to-Event Analyses
23/05/2019	Herpes zoster vaccine and the risk of Bell's palsy and Guillain-Barre Syndrome in the UK
23/05/2019	Developing and validating an optimised tool to identify familial hypercholesterolaemia in routine primary care (FAMCAT 2)
23/05/2019	Nature and duration of lipid modifying therapy prescription in response to potential statin intolerance in the UK: an observational study
23/05/2019	Utilization, safety and effectiveness of pharmacological therapy in gestational diabetes
22/05/2019	Assessment of Long-Term Bowel Dysfunction in Rectal Cancer Survivors – A Population-Based Cohort Study
22/05/2019	Incidence of opportunistic infections in patients diagnosed with inflammatory bowel disease: a population-based cohort study
22/05/2019	Effect of Long-Term Exposure to Anticholinergic Drugs on Dementia, an Emulated Target Trial
22/05/2019	The effect of smoking on BMI amongst COPD patients compared with controls: a retrospective cohort study using the CPRD GOLD database
21/05/2019	Classification and prediction of missing ethnicity in diabetic patients from electronic health record data
21/05/2019	Non-steroidal anti-inflammatory drug use and the risk of revision of lower joint replacement: A retrospective cohort study