Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/03/2019	Juvenile Idiopathic Arthritis (JIA): occurrence, comorbidity and healthcare utilisation
18/03/2019	Defining obesity cut-off points for the risk of type 2 diabetes, cardiovascular disease, and cancer among minority ethnic groups: a prospective cohort study using population-based linked electronic health records
18/03/2019	Developing and validating a novel clinical severity index for cardiovascular disease in primary care
18/03/2019	Data analysis of the current treatments for major depressive disorder and treatment resistant depression in the United Kingdom
13/03/2019	Bereavement amongst those with chronic kidney disease - does it affect outcomes?
13/03/2019	Epidemiology of Endometriosis in the Adolescent Population
13/03/2019	Ethnic differences in the prescribing of anti-diabetic, antihypertensive and lipid-lowering medication for people with and without type 2 diabetes
13/03/2019	Delayed treatment intensification and risk of micro- and macrovascular complications in insulin-treated patients with type 2 diabetes; a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
13/03/2019	Risk of Nephrotic Syndrome in Children with Atopic Eczema – a matched case-control study
12/03/2019	Determining the optimal timing of triple therapy initiation in patients with chronic obstructive pulmonary disease (COPD) in the United Kingdom (UK): A retrospective, longitudinal cohort study
12/03/2019	Database - Prescription Event Monitoring (D-PEM) study to identify, quantify and characterise identified adverse events associated with the use of a widely prescribed medication in primary care in the UK
12/03/2019	The impact of the National Data Opt-out programme on representativeness of the Clinical Practice Research Datalink (CPRD) database
11/03/2019	Weight change following type 2 diabetes diagnosis and incidence of cardiovascular events and all-cause mortality
11/03/2019	A matched population-based case control study to determine which clinical features are associated with the inherited cardiac conditions, bicuspid aortic valve and long QT syndrome in primary care
11/03/2019	Epidemiology of osteoarthritis and associated comorbidities: a combined case-control and cohort study
07/03/2019	A personalized approach to depression care: Discovering adaptive treatment strategies
07/03/2019	Development and internal validation of prognostic scores for risk of lower limb amputation and all-cause mortality in patients at risk of developing diabetic foot problems, and in patients with diabetic foot ulcer
07/03/2019	Prevalence of prescription of blood pressure lowering drugs, statins and aspirin, and their effects on BP and cholesterol when taken alone and together
07/03/2019	Cardiovascular disease in a general asthma population: UK population study
28/02/2019	Progression rates and risk factors for type 2 diabetes and cardiovascular disease in individuals diagnosed with gestational diabetes mellitus: A retrospective cohort study using CPRD