Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
25/02/2019	Costs and clinical consequences of gastrointestinal bleeding events in patients with atrial fibrillation
22/02/2019	The association between fracture risk and diabetes duration, complications and regulation in diabetes mellitus
22/02/2019	Characteristics of lung cancer patients in clinical practice and potential study eligibility for clinical trials evaluating tyrosine kinase inhibitors or immune checkpoint inhibitors.
22/02/2019	Understanding the harms of antihypertensives, statins and antiplatelets for prevention of cardiovascular disease: A prognostic modelling and casual inference study
22/02/2019	Medical conditions and medications potentially associated with lung cancer in a population of never smokers in CPRD
21/02/2019	The impact of musculoskeletal conditions on outcome of hospital care for acute coronary syndrome and stroke: a linked electronic health record study
21/02/2019	Characterisation and natural history of non-exacerbating chronic obstructive pulmonary disease patients in a general practice-based population
21/02/2019	All-cause Mortality in Infants vaccinated in the routine childhood immunisation schedule in general practice in the United Kingdom
21/02/2019	Characteristics of patients initiating Spiriva Respimat in Asthma in the UK: a cross-sectional study based on the Clinical Practice Research Datalink
14/02/2019	Comparative safety profile of antidiabetic drug regimens containing SGLT-2 inhibitors and/or GLP-1 receptor agonists among type 2 diabetes patients
12/02/2019	What are the optimal blood pressure targets for patients in atrial fibrillation treated with non-vitamin K antagonist oral anticoagulants?
12/02/2019	Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture
11/02/2019	Evaluation of clinical progression of chronic kidney disease and its predictors using statistical and machine learning techniques: a retrospective cohort study from United Kingdom
11/02/2019	Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
11/02/2019	The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
08/02/2019	Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019	Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
08/02/2019	Trends in incidence of first diabetic foot ulcer and mortality in patients with type I and type II diabetes mellitus
08/02/2019	Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
07/02/2019	Validation of Asthma-COPD Overlap Syndrome in the Clinical Practice Research Datalink (CPRD)