Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/12/2018	The Health Economic Burden of Atopic Dermatitis and Associated Dermatologic Conditions: A Study of Cow's Milk Allergy (CMA) in patients > 5 years of age in the Primary and Secondary Care Pathways
19/12/2018	Testing a data-based definition of severity in atopic dermatitis in a linked primary and secondary care dataset in England: Implications on clinical outcomes and healthcare resource use
17/12/2018	Linaclotide Safety Study for the Assessment of Diarrhoea - Complications and Associated Risk Factors in the UK population with IBS-C
14/12/2018	Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and diverse non-cardiovascular diseases: a population-based cohort study of England using linkage dataset
14/12/2018	Patient characteristic and treatment pattern for uncontrolled adult type 1 diabetes patients: a cross-sectional analysis to support economic modelling activities in a UK-specific context
14/12/2018	Translation of the electronic Frailty Index for use with the International Statistical Classification of Diseases and Related Health Problems tool in hip and knee replacement patients
11/12/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 3 -Replication of "Non-persistence and non-adherence of patients with Type 2 Diabetes Mellitus in Therapy with GLP-1 Receptor Agonists: A Retrospective Analysis"
11/12/2018	Mental illness: changes in incidence, prevalence, treatment and outcomes 2000-2018
11/12/2018	Identifying population groups at risk of avoidable hospitalisations for community acquired pneumonia in the UK.
11/12/2018	Evaluating the risk of macrovascular events, disability, and mortality in individuals with multiple sclerosis in England: a population-based retrospective cohort study
11/12/2018	The Costs and Complications of Colostomy, Ileostomy and Urostomy in England in Primary and Secondary Care: A 10-Year Study using Real World Datasets
11/12/2018	An external validation of the SAFEHEART vascular event risk prediction model in a UK routine care cohort with familial hypercholesterolaemia
11/12/2018	All-cause and cardio-renal-metabolic mortality in people with or without type 2 diabetes: a comparative international trend study
05/12/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 20 - Replication of "Risk of Death and Cardiovascular Outcomes with Thiazolidinediones: A Study with the General Practice Research Database and Secondary Care Data"
05/12/2018	Blood eosinophil levels as independent risk factor of severe asthma exacerbations and mortality in adult patients with asthma
05/12/2018	Fibrosing lung diseases: determinants, prognosis, and disease prediction
30/11/2018	Clusters of Chronic Obstructive Pulmonary Disease (COPD) co-morbidities and their relevance to mortality, service use, age and socioeconomic status.
30/11/2018	Prescriptions for antibiotics in childhood and risk of inflammatory bowel disease: A matched case-control study in the UK Clinical Practice Research Datalink
30/11/2018	REPEAT Study 17 - Replication of "Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study"
28/11/2018	Bone pain in primary care patients newly diagnosed with multiple myeloma: a population-based cohort study