Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
05/02/2019	The association of cancer and autism spectrum condition in a UK population
05/02/2019	Type 2 Diabetes in women after a diagnosis of gestational diabetes: understanding uptake to screening and progression rates- a retrospective cohort study in the CPRD database
04/02/2019	Estimating the prevalence of transthyretin amyloid cardiomyopathy in the UK
01/02/2019	Characterising end of life health care expenditure
29/01/2019	Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
29/01/2019	Fractured wrist; predictors of poor long-term clinical and socioeconomic outcomes (The FILTER Study)
29/01/2019	Improving treatment of people with dementia and additional health conditions
25/01/2019	Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease - Cross-sectional and Cohort Studies
24/01/2019	C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
24/01/2019	Characterizing type 2 diabetes mellitus (T2DM) patients trajectories and health outcomes - understanding and predicting co-morbidities, risk factors and complications
23/01/2019	Measurement of dementia disease progression in primary care: a cohort study
22/01/2019	Life-Limiting Conditions: the health of children and their Mothers
22/01/2019	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 14 - Replication of “Cardiovascular risks in smokers treated with nicotine replacement therapy: a historical cohort study”
21/01/2019	The association between prescription opioids and risk of bone fracture: a self-controlled case series study using the Clinical Practice Research Datalink
21/01/2019	Cardiovascular disease in homeless individuals: epidemiology, risk prediction and management
21/01/2019	Comparative effectiveness of first line anti-hypertensive agents stratified by age and ethnicity
17/01/2019	Recording of anxiety diagnoses and symptoms in primary care and trends in prescribing for anxiety
17/01/2019	Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
17/01/2019	Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
17/01/2019	Identifying predictors of drug treatment response in bipolar disorder