Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
11/10/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT):Study 15 - Replication of "Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events."
11/10/2018	Incretin-based drugs and the risk of lung cancer in patients with type 2 diabetes
11/10/2018	SGLT-2 Inhibitors and the Risk of Community-acquired Pneumonia
09/10/2018	Incidence of Cervical Intraepithelial Neoplasia (CIN) among women aged 18 years and above in the UK between 2000 and 2017
03/10/2018	A cross sectional description of prostate cancer subgroups
28/09/2018	The Natural History and heterogeneity in progression of Dementia in the United Kingdom
28/09/2018	Towards an accessible methodology in precision medicine: methods for time-to-event data and non-regular inferences with an application to treatment of type 2 diabetes
28/09/2018	Improved characterization of the overlap syndrome of heart failure, atrial fibrillation and acute coronary syndromes
24/09/2018	Identifying patients with familial hypercholesterolemia who could benefit from treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Development and validation of a logistic regression predictive model
21/09/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 7 - Replication of "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis"
20/09/2018	An investigation of the adverse outcomes and resource use associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and their relationship with glucocorticoid (GC) treatment
20/09/2018	The resource use, financial costs and related epidemiology of treating people with HIV and its associated comorbidities vs. matched controls in the UK general population
20/09/2018	Autoimmune blistering diseases: Incidence, prevalence, co-morbidity and prescription patterns
19/09/2018	Infants’ and Children’s Primary and Secondary Health Care Costs associated with mode of Childbirth and Gestational Age at Birth
19/09/2018	Impact of EU label changes for systemic diclofenac & hydroxyzine products: post-referral prescribing trends
12/09/2018	Feasibility study to assess the availability of appropriate records to support a retrospective, comparative, non-interventional cohort study to investigate the risk of drug induced liver injury associated with ulipristal acetate
11/09/2018	Difference in Response to Inhaled Corticosteroids between smoking and non-smoking asthma patients.
11/09/2018	Uptake of pneumococcal and zoster vaccines by clinical risk groups in England
10/09/2018	Mortality trends in people with and without type 2 diabetes in UK: a CPRD observational study
10/09/2018	Referral rates of severe asthma patients to asthma specialists in the UK and the impact on healthcare use