Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
25/04/2018	The effect of smoking on post-operative complications following hip or knee joint replacement
20/04/2018	Mapping the Multimorbidity Burden in Patients with Type-2 Diabetes Mellitus and Coronary Heart Disease
20/04/2018	Identifying and Evaluating Modifiers of Subsequent Event Risk among Patients with Established Coronary Heart Disease
20/04/2018	Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
20/04/2018	Prescription medications for cardiovascular disease and metabolic syndrome and risk of endometrial and ovarian cancer in the Clinical Practice Research Datalink
18/04/2018	Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome
18/04/2018	A retrospective observational study describing the health impact of SABA over-prescription and ICS under-prescription among asthma patients
18/04/2018	Trends in antipsychotic prescribing for children in UK primary care
18/04/2018	Meeting the physical healthcare needs of people with serious mental illness in primary care
18/04/2018	Antibiotic Choice in UK General Practice - rates and drivers of potentially inappropriate antibiotic type in UK general practices
18/04/2018	Cessation of renin-angiotensin system inhibitors after acute kidney injury and outcome
11/04/2018	Utilisation of Ulipristal acetate 5mg, long-term treatment patterns, resource utilisation in a population-based cohort in UK using the THIN and CPRD databases
11/04/2018	Epidemiology of amyloidosis in the United Kingdom
09/04/2018	Understanding the physical harms associated with the use of combined antipsychotic medication in people with schizophrenia
06/04/2018	Weight change and the onset and progression of cardiovascular diseases in large scale electronic health records
05/04/2018	Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD or PAD
05/04/2018	Gabapentinoid drug prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink
05/04/2018	Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with Congestive heart failure (CHF), and patients with CAD and CHF
05/04/2018	Comparison of Outcomes for Patients Hospitalised for Heart Failure (HHF) in the UK, Japan, USA and Taiwan
05/04/2018	Abdominal pain in primary care: establishing a clinical profile and diagnostic pathway for identifying cancer