Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
15/05/2018	The association between inflammatory markers measured in blood and incident seizures
15/05/2018	A quasi-experimental study to assess the effectiveness of an educational intervention for improving identification and management of familial hypercholesterolemia in general practice
15/05/2018	The risk of incident osteoarthritis of the hand in women with new use of estrogen replacement therapy or raloxifene: a cohort study with a nested case-control analysis
15/05/2018	Paracetamol versus Ibuprofen and the risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding and Renal Impairment
04/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
04/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 10 - Replication of "Prevalence and Burden of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease Managed in Primary Care"
02/05/2018	The risk of community-acquired pneumonia in children using proton pump inhibitors or histamine-2 receptor antagonists: a population-based cohort study in the United Kingdom
02/05/2018	Describing the Cumulative Anticholinergic Burden in Patients Over the Age of 65, With Overactive Bladder, and the Association to Healthcare Resource Utilization. A Retrospective Observational Study Using UK Electronic Medical Records (EMR) data.
02/05/2018	Impact of removing Quality and Outcomes Framework financial incentives from English Primary Care
30/04/2018	Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
30/04/2018	The epidemiology and healthcare burden of opioid therapy in the United Kingdom
30/04/2018	Mortality and morbidity effects of long-term exposure to low-level PM2.5, Black Carbon, NO2 and O3: an analysis of European cohorts
30/04/2018	The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis
27/04/2018	Using Predictive Analytics to Improve Patient Outcomes in Neuroendocrine Tumours
26/04/2018	A cohort study of infections and lymphopenia in eczema
26/04/2018	Blood Eosinophil Levels and Severe Asthma Exacerbations Among Paediatric Patients with Asthma in the English Primary Care Setting
26/04/2018	Are improvements in chronic respiratory disease management in England associated with reductions in excess mortality?
26/04/2018	5-ASA in Crohn's Disease: The CROHN'S Investigation (Clinical and treatment Resource use, patient Outcomes and Health impact using National prescribing Systems)
25/04/2018	Mapping opportunities for earlier detection of Bipolar Disorder - Linking big data to improve patient outcomes (MOBILISE)
25/04/2018	Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)