Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
03/04/2018	Improving care and cardiovascular health status for adults with osteoarthritis at risk of cardiovascular disease
03/04/2018	Healthcare resource utilisation associated with hepatocellular carcinoma in the UK
03/04/2018	Individual-level cost-of-illness Analysis for FoResight and Modelling for European HEalth Policy and Regulation (FRESHER) Project using linked English Data
03/04/2018	Heart failure as a risk factor for acute exacerbations of COPD (AECOPD)
03/04/2018	REPEAT: Study 9- Replication of "Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis"
28/03/2018	A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants (DOACs) versus. Warfarin in Older People with Atrial Fibrillation
28/03/2018	Predicting Type-II Diabetes Using Primary Care information
28/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 8 - Replication of "Incidence of type 2 diabetes after bariatric surgery"
28/03/2018	Utilisation pattern of hormonal replacement therapy in UK general practice between 2000 and 2016
26/03/2018	Risks of glucocorticoid therapy in PMR and GCA patients with co-existing type 2 diabetes
26/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 2 - Replication of "Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study"
26/03/2018	Beta 2 agonists and the incidence of Parkinson's disease
21/03/2018	Survival of patients with heart failure in community (SurviveHF)
20/03/2018	Dosage regimens and interrupted treatment in heart failure: a national retrospective cohort study in primary care.
20/03/2018	Exploring ethnicity as a risk factor for post-stroke dementia: a cohort study using the UK Clinical Practice Research Datalink
20/03/2018	Identifying predictors of adherence to diabetes medications: an observational cohort study
20/03/2018	Gout and Neurodegenerative Disorders: A retrospective cohort study in the Clinical Practice Research Datalink
19/03/2018	Risk factor trends and aetiological mechanisms leading to Heart Failure (HF) and outcomes; a study of ethnicity, gender and deprivation in the UK general population
19/03/2018	The progression of ischaemic heart disease to heart failure in different ethnic groups; a contemporary population-based cohort study in England
19/03/2018	Migraine in the UK: A descriptive cohort study of the burden of disease and health care resource utilisation