Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/05/2022	Can we diagnose rare Antinuclear antibody (ANA)-associated autoimmune diseases earlier? A matched cohort study of ANA positive patients.
12/05/2022	A retrospective cohort study of the epidemiology and clinical management of pemphigus in England
12/05/2022	Temporal profile of comorbidities pre- and post-diagnosis of epilepsy
10/05/2022	CHAracterization and treatMent Pathways of Heavy Menstrual Bleeding (HMB) (Acronym: Champion-HMB)
09/05/2022	Exploring triptan use and treatment sequencing for the management of migraine in the United Kingdom
09/05/2022	The epidemiology of endocrine, nutritional and metabolic diseases in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
09/05/2022	Migraine burden during pregnancy and associated maternal and offspring outcomes
09/05/2022	The association between comorbid mental illness and acute asthma exacerbations for adults with asthma: a UK based retrospective cohort study using primary care data.
09/05/2022	Personalising renal function monitoring and interventions in people living with heart failure: RENAL-HF
06/05/2022	Epidemiology of vasomotor symptoms and sleep disturbances in menopausal women: a multi-country secondary data retrospective cohort study using the Observational Health Data Sciences and Informatics network
06/05/2022	Medication adherence and persistence in patients with chronic obstructive pulmonary disease newly initiating long-acting maintenance therapy in the United Kingdom in a real-world primary care setting.
06/05/2022	The epidemiology of diseases of the skin and subcutaneous tissue in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
04/05/2022	Infection with Epstein Barr-Virus and risk of multiple sclerosis: a matched cohort study using the Clinical Practice Research Database (CPRD)
03/05/2022	A cohort study of cancers and mortality comparing warfarin and direct oral anticoagulants
03/05/2022	The epidemiology of diseases of the respiratory system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
29/04/2022	Neurodevelopmental outcomes of offspring born to mothers with Gestational Diabetes Mellitus compared to offspring born to mothers without Gestational Diabetes Mellitus
28/04/2022	Access to medication reviews and their impact on polypharmacy in primary care for adults aged 65 years and over
28/04/2022	Defining multimorbidity clusters of adults with similar long-term conditions and patterns of disease development using unsupervised clustering methods
28/04/2022	Safety of COVID-19 vaccination during pregnancy in England: a cohort study
27/04/2022	Feasibility study to replicate the Adverse Events of Special Interest for COVID-19 study in the CPRD Aurum Common Data Model and native data.