Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
09/06/2020	Investigating the impact of frailty on the risks and benefits of hip and knee replacement surgery
09/06/2020	Exploring the role of electronic Frailty Index (eFI) using routine primary care electronic health care records data to predict hospitalization and mortality in older patients with type 2 diabetes
09/06/2020	Retrospective cohort study to estimate age-stratified cardio-respiratory and exacerbations of diabetes outcome rates to support influenza vaccine rVE study planning in Europe
08/06/2020	Exacerbations and their Outcomes (EXACOS): Understanding the pathway to exacerbations of COPD and the association between frequency of exacerbations and risk of clinical and health-care utilization outcomes
08/06/2020	A comparison of the prevalence of electronic health record diagnoses of herpes zoster and simplex with self-reported prevalence from national population surveys and cohorts from the United Kingdom
08/06/2020	Developing the optimum strategy for coeliac disease case finding in adults and children
02/06/2020	Reducing the burden of recurrent wheeze in preschool children in England: A birth cohort study
02/06/2020	Clinical contact with health services for mental illness and self-harm before, during and after the COVID-19 pandemic
28/05/2020	Trend and mechanism of socioeconomic disparity in infant mortality
28/05/2020	Effect of metformin on incident dementia risk among adults with type 2 diabetes
28/05/2020	Antithrombotic treatment and outcome of patients with acute ischemic stroke and no atrial fibrillation: A real-world study in Clinical Practice Research Datalink
28/05/2020	Surgical interventions to treat severe pressure sores – The SIPS study
28/05/2020	Using the Clinical Practice Research Datalink to test medications associated with increased risk of upper gastrointestinal cancer identified from a Scottish screening study
28/05/2020	A qualitative questionnaire based study exploring attitudes, beliefs and experiences of patients and healthcare professionals, in relation to short-acting beta-2-agonist and inhaled corticosteroid prescription and adherence
28/05/2020	Intra-articular Corticosteroid injections in Osteoarthritis; the RUbICOn study
28/05/2020	Glycaemic Control in Type 2 Diabetes Patients after Switching from Basal-Bolus Treatment to Biphasic Insulin Aspart 30/70: a Descriptive Study
28/05/2020	Investigating inflammatory conditions in relation to colorectal cancer incidence and mortality by subsite and clinical features at presentation
19/05/2020	Understanding the diagnosis and prognosis of the presentation of breathlessness in adults from primary care
19/05/2020	Early Life Antibiotic Exposure and Incident Chronic Diseases in Childhood
19/05/2020	Prevalence, patient characteristics and treatment patterns of adult Atopic Dermatitis in UK primary care