Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
14/03/2018	5-alpha reductase inhibitors for benign prostate hyperplasia and the risk of urological cancers and other non-cancer adverse events
14/03/2018	Evaluating and Discovering Indicators of Care from Observational Data: A Case Study on Atrial Fibrillation
13/03/2018	Safety of reducing AB prescribing in primary care. Systematic new evidence from electronic health records
13/03/2018	Predictive value of cancer for dementia in cohorts with and without T2DM: a national observational study
13/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Replication of "Identification of impaired fasting glucose, healthcare utilization and progression to diabetes in the UK using the Clinical Practice Research Datalink (CPRD)".
13/03/2018	Rheumatological conditions as risk factors for self-harm. A retrospective cohort study
13/03/2018	Cholesterol lowering medications and risk of fatty liver disease and liver cancer
13/03/2018	Utilization and Adverse Outcomes of Ondansetron and Fluconazole Therapy during Pregnancy
13/03/2018	Prevalence of current asthma in the UK and changes over time with treatment
13/03/2018	Distal Renal Tubular Acidosis and Cystinuria in Adult and Paediatric populations: epidemiology, patient pathways and costs in the U.K
09/03/2018	Evaluating and enhancing the primary care medicines review in patients with complex health needs
08/03/2018	Blood eosinophil and creatine reactive protein as biomarkers of response to inhaled corticosteroids in COPD
08/03/2018	Statin use in chronic obstructive pulmonary disease (COPD) patients and risk of exacerbations: a propensity score matched cohort study
08/03/2018	An observational retrospective cohort analysis in adults with systemic lupus erythematosus/lupus nephritis to describe the characteristics of disease severity, disease activity (flare frequency), treatment, costs, and outcomes
08/03/2018	Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study
06/03/2018	Is smoking a risk factor for autoimmune hepatitis? An English registry-based case-control study using data from the Clinical Practice Research Datalink and linked Hospital Episode Statistics
06/03/2018	Evaluation of the patterns of presentation and treatment of cough in order to understand the prevalence and epidemiology of chronic cough: a preliminary investigation
05/03/2018	Prescribing trends of gabapentinoids in UK primary care
05/03/2018	Identifying coincident drugs that alter headache progression and remission.
01/03/2018	COMIX – Comorbidity index for predicting mortality in clinical studies as well as comparing its performance to existing comorbidity indices.