Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
28/02/2018	Developing tools for preventing delirium in primary care
28/02/2018	Longitudinal trends in continuity of care in English general practice
28/02/2018	Causes of mortality in patients with comorbid COPD and heart failure in the United Kingdom, 2005-2017
23/02/2018	Real-World Evidence in Oncology in England: Treatment patterns and Healthcare Resource Utilization
23/02/2018	Real-World Evidence in Oncology in England: Epidemiology, Patient Characteristics and Survival
22/02/2018	Identification of patterns of symptoms and comorbidities presented to primary care prior to diagnosis of first episode psychosis: an electronic health record study
22/02/2018	Epidemiology of pre-diagnosed rheumatoid arthritis and early classification of high severity at diagnosis
19/02/2018	Distribution of COPD patients by COPD GOLD Classification and their primary health-care and respiratory medication utilization in the Clinical Practice Research Datalink (CPRD)
19/02/2018	Characteristics of patients initiating and switching oral anticoagulants (OACs) for non-valvular atrial fibrillation (NVAF) in the UK general practices
16/02/2018	Comparative effectiveness of initial bronchodilator therapies in COPD
15/02/2018	Investigating pregnancies without recorded outcomes in the Clinical Practice Research Datalink / London School of Hygiene and Tropical Medicine Pregnancy Register, with the aim of improving validity.
15/02/2018	Risk and clinical impact of nontuberculous mycobacterial disease (NTM) within the general and chronic respiratory disease UK primary care patient populations, 2006-2016.
14/02/2018	Is patient-level achievement of primary care diabetes standards associated with emergency hospital admissions, mortality, non-traumatic amputation and/or diabetic retinopathy among the population with type 2 diabetes? A national observational study
13/02/2018	Determining profiles of musculoskeletal health using electronic health records
13/02/2018	Risk of Serious Infections in Patients with Psoriasis: a Cohort Study using the Clinical Practice Research Datalink
13/02/2018	Eczema phenotype discovery using cluster analysis techniques in CPRD
13/02/2018	Epidemiology of von Willebrand Disease in the UK (1989-2016): Prevalence, treatment patterns, descriptive characteristics, and incidence and prevalence of various outcomes and co-morbidities based on routine clinical care.
08/02/2018	Evaluating the impact of changes in hypertension guidelines on the management of hypertension and outcomes.
08/02/2018	Chronic kidney disease stage G3-G5 and the risk of subsequent fractures after hip fracture
06/02/2018	The association of concomitant use of potentiating drugs and bleeding risk during treatment with direct oral anticoagulants: a case control study