Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
18/12/2017	Use of metformin add on to insulin among patients diagnosed Type 1 diabetes mellitus in UK
18/12/2017	Risk factors for venous thromboembolism and serious bleeding events in patients with active breast, prostate, ovary, colorectal and lung cancer
18/12/2017	Dementia and Musculoskeletal Pain: Consultation and Treatment Patterns in Primary Care
18/12/2017	Investigating the Association of Type of Anticoagulation Treatment for Non-valvular Atrial Fibrillation and Risk of Bleeding in England
18/12/2017	Assessing the Burden of Illness of Generalised Refractory Myasthenia Gravis in England, using the CPRD database
18/12/2017	Methodological guidelines for the use of regression discontinuity designs in clinical settings.
15/12/2017	The risk of myotoxicity, hepatotoxicity and acute pancreatitis in statin-exposed heart failure patients with or without concomitant use of sacubitril/valsartan - a case-control study using data of the Clinical Practice Research Datalink
08/12/2017	Risk of nephrotic syndrome among non-steroidal anti-inflammatory drug users: a population-based study in the United Kingdom
08/12/2017	A cohort study to identify physical and mental diagnoses associated with a subsequent diagnosis of attention deficit-hyperactivity disorder (ADHD) in children and young people using primary care and linked data.
28/11/2017	Comparative effectiveness of 4th line anti-hypertensive agents in patients with resistant hypertension; a population based cohort study
27/11/2017	Prescribing patterns of glucosamine containing products- a study using CPRD
27/11/2017	Healthcare Resource Utilization and Costs among Patients with and without Infection after Intramedullary Nailing for A Tibial Shaft Fracture
24/11/2017	Survival Analysis with Machine Learning for Predicting the Risk of Adverse Outcomes
24/11/2017	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 1 - Replication of "Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study"
24/11/2017	Treatment Patterns and Characteristics of Patients with Uterine Fibroids in the UK: A Retrospective Cohort Study
22/11/2017	Inhaled corticosteroids, blood eosinophils and lung function (FEV1) decline over time in a primary care COPD cohort
22/11/2017	Outcomes following empirical antibiotic treatment of suspected urinary tract infection in older people in primary care.
21/11/2017	An exploratory study on the consistency and temporal variation of renal function of T2DM patients over time.
21/11/2017	Examining if primary care consultation patterns can identify children who go on to develop severe chronic kidney disease: a case-control study.
17/11/2017	Metabolic effects in children and adolescents treated with psychotropic medication in primary care