Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/02/2018	Incretin-based drugs and the incidence of cholangiocarcinoma among patients with type 2 diabetes.
06/02/2018	Completion of Recommended Hepatitis Vaccination Schedules Among Adults in the United Kingdom
05/02/2018	Prevalence of gas trapping in COPD - estimation from spirometry
05/02/2018	Aripiprazole and risk of psychiatric treatment failure
01/02/2018	Incidence of Type II Diabetes in Chronic Obstructive Pulmonary Disease
30/01/2018	The risk of angioedema and other specific safety events of interest in association with use of sacubitril/valsartan in adult patients with heart failure - a cohort study
24/01/2018	Epidemiology study of Invasive Extra-Intestinal pathogenic Escherichia coli (ExPEC) Disease in adults and elderly using real world healthcare databases
24/01/2018	Comparison of methodologies for establishing NHS Health Check pre-screening strategies using existing electronic health records
24/01/2018	Preterm birth and long-term risk of cardio-metabolic diseases
24/01/2018	Feasibility study to establish the value of linked CPRD and HES data to support medical device vigilance
24/01/2018	Antipsychotic prescribing and subsequent risk of fractures and death in people aged 80 years and over: A cohort study using electronic health records.
23/01/2018	Morbidity and mortality of UK smokers relative to non-smokers: cohort analysis
22/01/2018	Partner bereavement and subsequent diagnosis of specific skin diseases
22/01/2018	Antidepressant use during pregnancy: assessing benefits to mothers and long-term neurodevelopmental risks to children
18/01/2018	Bendroflumethiazide versus Indapamide for Primary Hypertension: Observational (BISON) study within CPRD
18/01/2018	A study of pneumonia following self-limiting respiratory tract infections managed in primary care
17/01/2018	Cardiovascular and cerebrovascular safety of testosterone replacement therapy in hypogonadal men
17/01/2018	Lifestyle and socio-economic risk factors for non-valvular atrial fibrillation
15/01/2018	Excess risk and predictors of fracture/s following bariatric surgery for obese patients in the NHS: a real-world self-controlled case series and cohort study
15/01/2018	Determining health outcomes and resource utilisation associated with hyperkalemia in the UK.