Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
17/11/2017	Exploratory study of cardiovascular risk in early type 2 diabetes
15/11/2017	Asthma, chronic obstructive pulmonary disease (COPD) and heart failure: a population-based cohort study of disease sub-classification, disease coexisting, and the underlying biological mechanism.
15/11/2017	Proton pump inhibitors and mortality: a cohort study
06/11/2017	Nalmefene use in the UK: prescribing patterns and influences
03/11/2017	Screening for atrial fibrillation at annual influenza vaccination of patients aged over 65; a cohort study.
03/11/2017	Treatment patterns and medication adherence to fluticasone furoate/vilanterol (FF/VI) and beclometasone/formoterol (BDP/F): a data characterisation study in the CPRD
03/11/2017	HIV as a risk factor in the initial presentation of a range of cardiovascular, coronary, cerebrovascular, and peripheral arterial diseases
03/11/2017	Estimation of the proportion of paediatric, adolescent and adult asthma patients according to modified GINA guidelines
30/10/2017	A UK population-based cohort study of risk factors for premature death in epilepsy
30/10/2017	Degree of serotonin reuptake inhibition of antidepressants and the risk of ischaemic stroke and myocardial infarction: a nested case control study
27/10/2017	What are the factors associated with missed opportunities to diagnose Chronic Obstructive Pulmonary Disease (COPD)? A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
27/10/2017	Paediatric Investigation Plans and estimating age in children within the Clinical Practice Research Database (CPRD)
27/10/2017	The association between continuity of primary care and mortality and emergency hospitalisation for older patients with complex multimorbidity
25/10/2017	Feasibility assessment of the potential post-authorization safety (PAS) study “Incidence of pancreatic cancer and thyroid neoplasm among type 2 diabetes patients who initiated exenatide as compared with those who initiated other glucose lowering drugs”
23/10/2017	The impact of polypharmacy on health outcomes in older patients: a retrospective cohort study using CPRD database.
23/10/2017	Natural History of Atrial Fibrillation in the United Kingdom
18/10/2017	The health care use and cost of care before and after the diagnosis of six selected endocrine diseases in UK patients
18/10/2017	The association between pain clinic attendance and healthcare/medication usage
17/10/2017	Polymyalgia rheumatica in primary care: an epidemiological investigation into occurrence and comorbidities.
17/10/2017	Real-world comparison of Qvar BAI versus Qvar MDI and all beclometasone MDI for the treatment of asthma based on a UK retrospective database study.