Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/09/2017	Progression of chronic kidney disease and the risk of severe infection, venous thromboembolism and major adverse cardiovascular event in patients with and without diabetes
19/09/2017	the safety and effectiveness of direct oral anticoagulants antagonists in conditions that elevate drug concentrations
19/09/2017	Clinical characteristics and healthcare resource utilization of Spinal Muscular Atrophy patients in the United Kingdom
19/09/2017	The effectiveness of CVD preventative treatment in a multi-morbid population
19/09/2017	Predicting medication adherence in patients with resistant hypertension
18/09/2017	National patterns in anti-asthmatic treatment in general practice: a descriptive study using data from the Clinical Practice Research Datalink.
13/09/2017	Treatment with DPP-4 inhibitors, adherence to Summary of Product Characteristics and therapy adjustment.
13/09/2017	Effect of major common infections on the incidence of post-stroke dementia: a cohort study using the UK Clinical Practice Research Datalink
13/09/2017	Quantifying the severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink
11/09/2017	Selective-recruitment designs for prospective observational studies of cardiovascular diseases using primary care electronic health records.
06/09/2017	Handling missing covariate data and changes in exposure status:
06/09/2017	Real World Effects of Medications for Chronic Obstructive Pulmonary Disease
01/09/2017	Variation in recording of alcohol use in CPRD: a cross-sectional study
01/09/2017	Epidemiology of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) in England: a retrospective observational study using CPRD-HES linked data
01/09/2017	Evaluation of Disease Burden and Treatment Patterns in Postpartum Depression: A Retrospective Observational Study of UK Practice
31/08/2017	Use of dipeptidyl deptidase-4 inhibitors and new-onset rheumatoid arthritis in patients with type 2 diabetes.
31/08/2017	Children and Adolescents with PaRental mental Illness: Understanding the 'who' and the 'how' of targetting interventions? 'CAPRI'
29/08/2017	Dipeptidyl deptidase-4 inhibitors and the incidence of inflammatory bowel disease among patients with type 2 diabetes.
29/08/2017	Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD/PAD
24/08/2017	Using longitudinal electronic health records to support evaluations of NHS England new care models – a retrospective analysis using the Clinical Practice Research Datalink.