Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
18/05/2020	Health care resource utilisation in pyruvate kinase deficiency patients in the UK: a retrospective database study using CPRD Gold and Aurum
15/05/2020	Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use
15/05/2020	Investigating population-wide differences in cancer disease trajectories: Identification of pre-cancer diagnostic routes and post-cancer disease trajectories in patients with multimorbidity using statistical and machine learning approaches
13/05/2020	Evaluating the clinical outcomes of antithrombotic therapy in patients with cirrhosis and atrial fibrillation or ischaemic heart disease
11/05/2020	Risk of cardiovascular and related diseases in asthma patients and bronchodilator users in the UK
11/05/2020	Incidence, Prevalence and Burden of Narcolepsy in Europe: A Multi-database Study
11/05/2020	Assessment of burden of illness of heart failure with reduced ejection fraction in the United Kingdom
05/05/2020	Consultations for non-specific symptoms commonly reported with COVID-19 and other acute respiratory infections in the Clinical Practice Research Datalink: long term trends and patient characteristics
05/05/2020	Antimicrobial stewardship during the COVID-19 epidemic. Cohort study
05/05/2020	The association between amoxicillin exposure in infancy and the development of asthma in later childhood in the UK: A retrospective cohort study using Clinical Practice Research Datalink
30/04/2020	Drug Utilisation Study extension (DUS ext.) of valproate and related substances, in Europe, using databases
30/04/2020	Exploring the relationship between NSAID prescribing and complications in patients with common infections
28/04/2020	Utilisation and safety of Glycopyrronium Bromide (GPB) oral solution for the treatment of sialorrhoea in children <18 years in the UK
28/04/2020	Assessing the long-term impact of infant rotavirus vaccination on the age-related risk of acute gastroenteritis and heterologous effects of vaccination in children: a cohort study
28/04/2020	A retrospective cohort study to describe primary and secondary healthcare use and associated costs, and patterns of investigation and treatment in adult patients with chronic cough in the United Kingdom
27/04/2020	Underlying conditions in coronavirus (COVID-19) infection: definition, prevalence, mortality and understanding risk
22/04/2020	Resource burden and treatment pathway for Type 2 Diabetic patients with Diabetic Kidney Disease in England: A study utilising primary and secondary care datasets
22/04/2020	Proton Pump Inhibitors and Gastric Cancer Incidence: A Population-based Cohort Study
20/04/2020	Examining the clinical and economic outcomes associated with cancer survivorship
20/04/2020	Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) Study