Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
20/04/2020	Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) Study
20/04/2020	Investigating early diagnoses of patients with ankylosing spondylitis using machine learning: a predictive modelling study
20/04/2020	Examining the clinical and economic outcomes associated with cancer survivorship
16/04/2020	COVID-19 and drugs acting on the renin angiotensin system
16/04/2020	Quantifying Bias in Epidemiological Studies on the Association Between Acetaminophen and Cancer 2
15/04/2020	Incidence and treatment of anxiety and depression in patients and families after a cancer diagnosis: a descriptive population-based study
15/04/2020	Cardiovascular safety of SGLT2 inhibitors in type 2 diabetes: The effect of obesity
15/04/2020	Investigating the feasibility of exploring health outcomes among caregivers in a primary care database
15/04/2020	Descriptive analysis of primary care consultations in England from 2000 to 2018
09/04/2020	Pharmacological risk factors for COVID-19 infection: a matched prospective cohort study of patients in primary care
08/04/2020	Historic trends and future projections of the consultation incidence and prevalence of osteoarthritis and low back pain in England: estimates from the Clinical Practice Research Datalink
08/04/2020	Description of routine diagnostic tests performance in primary care
01/04/2020	PERsonalised Medicine for Intensification of Treatment (PERMIT): the case of type 2 diabetes mellitus
01/04/2020	Thyroid hormone replacement therapy and the risk of major adverse cardiovascular events (MACE) among individuals with mild subclinical hypothyroidism
31/03/2020	Improving English national cancer registration using CPRD to reduce the number of Death Certificate Only cases: a descriptive feasibility study
31/03/2020	Clustering of multi-morbidity in stroke survivors
31/03/2020	The use of primary care services among individuals with dementia approaching the end-of-life, and its association with multiple hospital admissions: a retrospective cohort study
27/03/2020	Cardiovascular disease in type 2 diabetes: characterisation of treatment variation in the UK CPRD
27/03/2020	An Evaluation of Risk Factors, Treatment Patterns and Outcomes Among Patients Treated with Lipid Lowering Therapy in the United Kingdom from 2008 to 2017
27/03/2020	A primary care-based cohort study evaluating the utility of indefinite regular monitoring blood tests in detecting asymptomatic toxicity from long-term methotrexate and leflunomide prescription