Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
27/03/2020	An Evaluation of Risk Factors, Treatment Patterns and Outcomes Among Patients Treated with Lipid Lowering Therapy in the United Kingdom from 2008 to 2017
27/03/2020	A primary care-based cohort study evaluating the utility of indefinite regular monitoring blood tests in detecting asymptomatic toxicity from long-term methotrexate and leflunomide prescription
25/03/2020	Investigating the health and care needs of pregnant women with multimorbidity: A retrospective analysis of linked Primary and Secondary care data
25/03/2020	Identifying risk factors for infection with the new coronavirus (COVID-19)
25/03/2020	A retrospective database study characterising clinical pathways and healthcare resource utilisation among patients with iron deficiency (ID) or iron deficiency anaemia (IDA) in England
25/03/2020	Epidemiology of non-fatal self-harm, suicide and other causes of premature death following discharge from inpatient psychiatric care
24/03/2020	Developing a predictive Tool using data linkage and machine learning, to promote Earlier Diagnosis of Type 1 diabetes in childhood for use in primary care – the TED study
24/03/2020	Intermittent cessation of treatment for cardiovascular diseases and diabetes in breast or prostate cancer survivors and the risk of serious cardiovascular events: a matched cohort study
24/03/2020	An observational study of early versus late tapentadol initiation for the treatment of chronic pain: comparison of adverse events and resource use with morphine or oxycodone
23/03/2020	Characterisation, prediction of complications, and safety of emergent therapies for viral outbreaks and pneumonia: a rapid network study to inform management of COVID-19
13/03/2020	Identifying factors to improve management of school-age asthma in primary care: a UK population cohort study
13/03/2020	Analysing the effect of lithium cessation on renal function in patients with bipolar disorder
13/03/2020	Mental illness in atopic eczema and psoriasis: matched cohort studies
11/03/2020	Risk of death in childhood epilepsy
11/03/2020	Natural history of knee osteoarthritis with regards to other joint sites and knee replacement: a cohort study in the UK Clinical Practice Research Datalink
11/03/2020	Hospitalization rates, outcomes, and treatment intensity for elderly patients for hip fracture, acute myocardial infarction, ischemic stroke, elective aortic aneurysm repair, and heart failure
11/03/2020	Investigation of common mechanisms and clinical pathways in cardiovascular diseases and dementia
06/03/2020	Mental and cognitive disorders-related multimorbidity in primary care settings
04/03/2020	Measuring the incidence and prevalence of menstrual disorders in the UK Clinical Practice Research Datalink
04/03/2020	Risk factors for pertussis in older adults aged 50 years and above, and the incidence and economic burden of pertussis overall and in high-risk groups using the merged CPRD GOLD and Aurum database, and Hospital Episode Statistics (HES)